“瑰及”乳膏中白及不同提取部位活血化瘀作用的实验研究

Experimental Study on the Effect of Different Extracts from BletiUa Colloidon Promoting Blood Circulation and Removing Blood in GuiJi Cream

目的:探讨白及不同提取部位对大鼠的活血化瘀作用。方法:建立血瘀模型,测定大鼠体内血小板浆集率、血瘀大鼠全血、血浆和血清比黏度的影响。结果:白及正丁醇提取部位和水溶性部位可显著升高腺苷二磷酸(ADP)诱导的血小板最大聚集率,而乙酸乙酯提取部位可显著抑制ADP诱导的血小板聚集,石油醚提取部位对ADP诱导的血小板聚集无显著影响。缩论:白及乙酸乙酯提取部位能显著降低血瘀大鼠的全血比黏度、血浆比黏度及血清比黏度,是活血作用的主要有效部位,其活血作用与其抑制血小板聚集作用有关。

Objective：To study the Effects of different extracts from Bletilla colloid on rat platelet aggregation.Methods：Make the models of rats which arc with blood silted,Determine the indexes of hemorrheology, the effects on hemorheology and Blood Routine.The platelet aggregation rate was measured by turbidimctric method.Results：n-Butanol extract and water extract significantly enhanced and acetic ether extract from Bletilla colloid prominently reduced platelet maximum aggregation induced by ADP, while petroleum ether extract had no effect.Conclusion：Acetic ether extract from Bletilla colloid is major active extracts playing a part in hemostasis.The hemostasis effect is related to inhabiting the whole blood viscosity and platelet aggregation.