低温冷冻同种异体胎软骨移植的应用

Allotransplantation of cryopreserved fetal cartilage in plastic surgery

目的探讨同种异体胎软骨在整形外科应用的可行性。方法在无菌条件下切取死胎儿的四肢及肋软骨,经低温保护剂进行超低温冷冻-80℃,保存于-196℃的液氮中。经复温处理后应用于临床38例。其中鞍鼻畸形24例,外耳缺损4例,唇裂继发畸形6例,颏成形4例。结果经3年6个月随访。除2例外耳再造术后出现变形外,其余病例均无吸收、变形、免疫排斥反应,外形较为满意。结论同种异体胎儿软骨在整形外科有一定的应用价值。

Objective To study the applicability of homologous fetal cartilage in plastic surgery. Methods Limb and costal cartilage were taken from the dead fetus.The fetal cartilage was then frozen at -80℃ and preserved in-196℃ liquid nitrogen with a cryoprotective agent.A total of 38 patients re- ceived fetal cartilage transplantation.Of them there were 24 saddle nose,4 auricle defects,6 secondary de- formities of cheiloschisis,4 mandible deformities.Results Through follow-up of three and a half years,it was found that none of the transplanted cartilage was absorbed,deformed or rejected due to immunologicol reaction.The contours were satisfactory except 2 cases with auricle reconstruction.Conclusion The clini- cal application of homologous fetal cartilages is of value in plastic surgery.