通草及小通草多糖抗氧化作用的实验研究

Experimental Studies on Antioxidative Effect of Tongcao and Xiao Tongcao Polysaccharides

目的：观察不同品种通草及小通草多糖抗氧化作用。方法：将通草（通脱木）及３种小通草（喜马山旌节花、西南绣球、棣棠花）的总多糖提取物，以８０ｍｇ／ｋｇ和１６０ｍｇ／ｋｇ剂量腹腔注射给予９月龄小鼠４５ｄ，观察小鼠肝脏和血清过氧化脂质（ＬＰＯ）含量、小鼠全血超氧化物歧化酶（ＳＯＤ）活力及小鼠心、肝、脑组织中脂褐素（ＬＦ）含量的变化。结果：４种通草多糖较长时间腹腔注射给予９月龄小鼠，可明显降低小鼠血清和肝脏中ＬＰＯ含量，降低小鼠脑组织和心肌中ＬＦ含量，提高小鼠全血ＳＯＤ活力，对小鼠肝脏中ＬＦ含量影响不明显。结论：通草（通脱木）及３种小通草（喜马山旌节花、西南绣球、棣棠花）的总多糖提取物具有良好的抗氧化效应。

Objective:To observe the antioxidative effect of four kinds of Tongcao and Xiao Tongcao polysaccharides.Method:Aged mice(nine months)were abdominal administrated with four kinds of polysaccharides(Tongtuomu,Ximashanjingjiehua,Xinanxiuqiu,Ditanghua)at dosages of 160mg/kg and 80mg/kg for 45 days.Result:Four kinds of polysaccharides could obviously decrease the content of serum and liver lipoperoxide(LPO) as well as the content of lipofuscin(LF) in brain and cardiac muscle of aged mice,and also increase the activity of superoxide dismutase(SOD) of red cells in aged mice.Conclusion:The polysaccharide components of Tongtuomu and three kinds of Xiao Tongcao have antioxidative effect,suggesting that these substances have antiageing function.