新型鼻塞持续气道正压通气治疗新生儿肺透明膜病的疗效观察

The Effect of New Nasal Continuous Positive Airway Pressure in Treatment of Neonatal Hyaline Membrane disease

目的评价新型鼻塞持续气道正压通气（NCPAP）治疗新生儿肺透明膜病的疗效。方法 74例新生儿肺透明膜病患儿随机平均分为治疗组和对照组,治疗组采用新型鼻塞持续气道正压通气,设置参数为流量6~8 L/min,吸入氧浓度（FiO2）0.3~0.6,压力为4~8 cmH2O;对照组采用头罩吸氧（氧流量4~6 L/min）。治疗无效改用气管插管、机械通气治疗。观察两组患儿治疗疗效。结果治疗组33例治愈,3例改用气管插管,1例自动出院,治愈率89.2%;对照组13例治愈,22例改用气管插管,2例死亡,治愈率35.1%。两组治疗效果比较差异有统计学意义（P〈0.05）。结论 NCPAP治疗新生儿肺透明膜病具有良好的疗效,值得临床推广应用。

Objective To evaluate the therapeutic effect of new nasal continuous positive airway pressure（NCPAP） in treatment of neonatal hyaline membrane disease（HMD）.Methods 74 newborns with HMD were randomly divided into two groups,the treatment group and control group（both were 37 cases）.The cases in the treatment group were treated using New NCPAP system,the parameter setting were flow rate 6～8L/min,FiO2 0.3～0.6,pressure 4~8cm H2O.the cases in the control group underwent oxygen-absorbing by head set with the flow rate 4~6L/min.If the appointed therapy way failed in each group,the patients would started machine ventilation.Results Among the 37 cases in the treatment group,33 cases were healed,3 cases adopted machine ventilation,1 case was recovered and released,and the cure rate was 89.2%;and in the control group,13 cases were healed,22 cases underwent machine ventilation,2 cases died,and the cure rate was 35.1%.Conclusion The New NCPAP system is obviously effective in treating neonatal hyaline membrane disease and worth promotion clinically.