复发转移性食管癌的药物治疗

Medical treaUnent of advanced esophageal cancer

顺铂联合氟尿嘧啶仍是晚期食管癌的基本治疗方案；新的细胞毒药物如紫杉醇类、拓扑异构酶抑制剂及新联合方案是研究的热点；奥沙利铂可替代顺铂，口服氟尿嘧啶衍生物可替代静脉氟尿嘧啶治疗晚期食管癌；二线治疗研究已逐渐被接受和增多；分子靶向治疗将为食管癌提供更多、更好的选择。

Cisplatin in combination with fluorouracil still is considered as the basic therapeutic scheme for advanced esophageal cancer. New cytotoxic drugs, such as taxanes and topoisomerase inhibitor etc, and new regimens are focus researches for medical treatment. Intravenous fluorouracil can be replaced by oral fluorouracil derivative, and cisplatin can be replaced by oxaliplatin in the regimens of contained cisplatin and fluorouracil for advanced esophageal cancer. Patients with advanced esophageal cancer are now offered seconded line treatment, and the number of research protocols is increasing. Molecule targeted therapy as a promising treatment will provide more and better options for patients.