局限期小细胞肺癌的胸部放射治疗

Thoracic radiotherapy in limited-stage small cell lung cancer

局限期小细胞肺癌有效的治疗方式是放化疗联合治疗。放疗倾向于早期进行，而从治疗开始到放疗结束时间少于30d能显著提高生存率。同期放化疗较序贯及交替疗法更能延长生存时间。放疗的总剂量尚无明确的定论。加速超分割照射较常规照射可能会提高疗效。

The effective therapy of limited stage-small cell lung cancer（LS-SCLC） is combined chemotherapy and thoracic radiotherapy（TRT）. Early thoracic irradiation is better than later one. Start of any treatment and end of radiotherapy less than 30 days is associated with improved survival in LS-SCLC patients. Concurrent chemoradiotherapy results in longer survival time than sequential and alternating chemoradiotherapy. There are no clear answers on optimal irradiation dose. Hyperfractinated irradiation may have therapeutic benefit compared with conventional irradiation.