期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Th17细胞的分化调控与自身免疫性疾病 被引量：11

The differentiation and regulation of Th17 cell and autoimmune diseases
原文传递
导出
摘要 Th17细胞是最近发现的一种在分化和功能上均不同于Th1和Th2的新型CD4＋T细胞亚群.该群细胞以主要分泌细胞因子IL-17而得名.IL-6、TGF-β、IL-21及IL-23等对Th17细胞的分化调控发挥重要作用.研究表明,Th17细胞可参与多种自身免疫性疾病的发生、发展与转归. The latest revealed Th17 cell belongs to a new subgroup of CD4＋T cell which differs from Th1 and Th2 on differentiation and function.The cell is so named because of its characteristic of mainly excreting cytokine IL-17.Cytokine IL-6,TGF-β,IL-21 and IL-23 all of them play important roles in differentiation and regulation of Th17 cell.Studies showed that Th17 cell can participate in the development of mutiple autoimmne diseases.
作者 郭静雅 邱玉华
机构地区 苏州大学医学部免疫学系
出处 《国际免疫学杂志》 CAS 北大核心 2010年第4期249-252,共4页 International Journal of Immunology
基金 科技部重大专项资助项目（2009ZX09103-705）
关键词 TH17细胞 IL-17 自身免疫性疾病 Th17 cell Interleukin-17 Autoimmune diseases
分类号 R593.2 [医药卫生—内科学]
  • 相关文献

参考文献2

二级参考文献24

  • 1Yeonseok Chung,Xuexian Yang,Seon Hee Chang,Li Ma,Qiang Tian,Chen Dong.Expression and regulation of IL-22 in the IL-17.producing CD4+T lymphocytes[J].Cell Research,2006,16(11):902-907. 被引量：20
  • 2Lawrence Steinman A brief history of TH17, the first major revision in the TH1/TH2 hypothesis of T cell - mediated tissue damage. Nature Medicine, Review,2007,13 (2) : 139-145
  • 3Harrington LE, Hatton RD, Mangan PR, et al. Interleukin 17-producing CD4 + Effector T cells develop via a liesge distinct from the T helper type 1 and lineages. Nat Immuno1,2005,6 ( 11 ) : 1123 -1132
  • 4Park H, Li ZX,Yang XO, et al. A distinct lieage of CIM T cells regu latestissue Inflammation by producing interleukin 17. Nat Immunol, 2005,6( 11 ) :1133-1141
  • 5Ivanov,I. I. et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflarmnatory IL-17 + T helper cells. Cell,2006,126 : 1121-1133
  • 6Bettelli E, Oukka M, Kuchroo VK Th-17 cells in the circle of immunity and autoimmunity. Nature Immunol, 2006, 7(9) : 929-936
  • 7Chen Y, Langrish C L, Mckenzie B, et al. Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest ,2006,116 ( 5 ) : 1317-1326
  • 8Rho J, Takami M, Choi Y, et al. Osteoimmunology : interactions of the immune and skeletal systems. J Mol Cells ,2004,17 (1) :1-9
  • 9Nakajima H, Takamori H, Hiyama Y & Tsukada W. The effect of treatment with recombinant gamma-interferon on adjuvant-induced arthritis in rats. J Agents Actions, 1991,34:63 -65
  • 10Chabaud M, Page G, Miossec P. Enhancing effect of IL-1, IL-17, and TNF-alpha on macrophage inflammatory protein-3alpha production in rheumatoid arthritis: regulation by soluble receptors and Th2 cytokines. J Immunol,2001,167 :6015-6020.

共引文献51

同被引文献73

引证文献11

二级引证文献73

国际免疫学杂志
2010年 第4期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部