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白细胞介素-17与幽门螺杆菌感染所致胃疾病的相关性研究 被引量：6

Research in the correlation between interleukin-17 and H. pylori-induced gastric diseases
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摘要 幽门螺杆菌（Hp）是导致人类发生慢性活动性胃炎、消化性溃疡的主要病原菌,并且与胃腺癌、胃黏膜相关淋巴组织淋巴瘤的发生也密切相关.Hp诱导产生的白细胞介素-17（IL-17）作为第二信使招致粒细胞在局部聚集,是引起胃部炎症反应以及进一步病理损害的重要调节因子.在Hp感染性胃疾病中,胃粘膜中的IL-17蛋白表达明显增加. Helicobacter pylori （H. pylori or Hp） is the major pathogen which causes human chronic active gastritis and peptic ulcer. Hp is closely related to gastric adenocareinoma, gastric mucosa-associated lymphoid tissue lymphoma. As the second messenger,IL-17 induced by Hp aggregated of granulocyte cells in parts of stomach. IL-17 is an important regulator which causes stomach inflammation and further pathological damages. The expression of IL-17 protein in the gastric mucosa increased significantly in patients with gastric diseases caused by Hp.
作者 刘亚普 张艳
机构地区 湖南衡阳南华大学病原生物学研究所
出处 《国际免疫学杂志》 CAS 北大核心 2010年第4期273-276,共4页 International Journal of Immunology
基金 湖南省自然科学基金课题资助（06JJ2093） 湖南省教育厅青年基金课题资助（08B067）
关键词 IL-17 TH17细胞 幽门螺杆菌 胃疾病 IL-17 Th cells Helicobacter pylori Gastric disease
分类号 R573 [医药卫生—消化系统]
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参考文献3

二级参考文献24

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共引文献40

同被引文献101

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引证文献6

二级引证文献35

国际免疫学杂志
2010年 第4期

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