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泛素-蛋白酶体系统与免疫系统的关系 被引量：7

The ubiquitin-proteasome system and its role in immune system
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摘要 泛素-蛋白酶体系统是一种广泛存在于真核细胞内的依赖atp的高选择性的蛋白质降解体系，具有清除衰老、损伤以及错误折叠蛋白的功能，其在细胞周期调控、细胞凋亡、受体信号传导等过程中都有重要的作用。泛素-蛋白酶体系统与免疫系统之间联系密切，因而研究其在感染免疫、自身免疫和肿瘤免疫中的调控很有必要。 The ubiquitin-proteasome system （UPS） is an highly selective ATP-dependent proteolytic system in all eukaryotic cells. The function of UPS is eliminate the aged, damaged and/or .misfolded proteins. It plays a key role in many important processes such as in the regulation of the cell cycle , apoptosis, signalling. The UPS is also closely associated with the immune system, in this review, we described its the role of UPS in the regulation of infection immunity, autoimmunity and tumor immunity.
作者 陈建华 汤正好
机构地区 上海交通大学附属第六人民医院感染科
出处 《国际免疫学杂志》 CAS 北大核心 2010年第4期286-289,共4页 International Journal of Immunology
关键词 泛素-蛋白酶体系统 免疫系统 感染 自身免疫 肿瘤 Ubiquitin-Proteasome System Immune system Infection Autoimmune Tumor
分类号 R3 [医药卫生—基础医学]
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参考文献23

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  • 2Seifert U,Kruger E.Remodelling of the ubiquitin-proteasome system in response to intederons.Biochem Soc Trans,2008,36 (5):879-884.
  • 3Young LJ,Wilson NS,Schnorrer P,et al.Differential MHC class Ⅱ synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells.Nat Immunol,2008,9 (11):1244-1252.
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同被引文献208

  • 1倪晓光,赵平.泛素-蛋白酶体途径的组成和功能[J].生理科学进展,2006,37(3):255-258. 被引量：43
  • 2沈子珒,许啸声,李稻.泛素-蛋白酶体及其抑制剂[J].现代肿瘤医学,2006,14(11):1454-1457. 被引量：8
  • 3Festa RA, McAllister F, Pearce MJ, Mintseris J, Burns KE, Gygi SP, Darwin K H. Prokayrotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] [J]. PLoS One, 2010, 5 (1): e8589.
  • 4Sutter M, Striebel F, Damberger FF, Allain FH, Weber-Ban E. A distinct structural region of the prokaryotic ubiquitin-like protein (Pup) is recognized by the N-terminal domain of the proteasomal ATPase Mpal[J]. FEBS Lett, 2009, 583 (19): 3151-3157.
  • 5Burns KE, Pearce MJ, Darwin KH. Prokaryotic ubiquitin-like protein provides a two-part degron to Mycobaeterium proteasome substrates[J]. J Bacteriol, 2010, 192 (11): 2933-2935.
  • 6Hu G, Lin G, Wang M, Dick L, Xu RM, Nathan C, Li H. Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate[J]. Mol Mierobiol, 2006, 59 (5): 1417-1428.
  • 7Mukherjee S, Orth K. Micrabiology. A protein pupylation paradigm[J]. Science, 2008, 322 (5904): 1062-1063.
  • 8Cerda-Maira FA, Pearce MJ, Fuortes M, Bishai WR, Hubhard SR, Darwin KH. Molecular analysis of the prokaryotic ubiquitin-like protein (Pup) conjugation pathway in Mycobacterium tuberculosis [J]. Mol Microbiol, 2010, 77 (5): 1123-1135.
  • 9Goldberg AL. Protein degradation and protection against misfolded or damaged proteins[J]. Nature, 2003, 426 (6968): 895-899.
  • 10Burns KE, Liu WT, Boshoff HI, Dorrestein PC, Barry CE 3rd. Proteasomal protein degradation in Mycobacteria is dependent upon a prokaryotic ubiquitin-like protein[J]. J Biol Chem, 2009, 284 (5): 3069-3075.

引证文献7

二级引证文献22

国际免疫学杂志
2010年 第4期

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