白细胞介素10免疫调节功能的研究进展

Advances in the study of the immunological functions of Interleukin-10

白细胞介素10（IL-10）作为一种多效价的细胞因子,最初认为其主要由Th2细胞产生,随后的研究发现Th1、Th17、调节性T细胞（Treg）、Th9以及CD8＋T细胞和B细胞均可以产生IL-10 另外固有免疫细胞以及角质形成细胞、上皮细胞和肿瘤细胞等也产生IL-10.IL-10通过与细胞表面IL-IOR1和IL-IOR2相互作用并主要激活JAK.STAT通路发挥生物学作用.IL-10可以抑制抗原提呈细胞的活化,共刺激分子的表达以及提成抗原的能力,降低促炎性细胞因子的合成,参与免疫球蛋白（Ig）的类别转换以及介导肿瘤细胞免疫逃逸等的发生.IL-10在炎症,多种自身免疫病以及肿瘤,移植排斥反应等多种疾病的发生和发展过程中都有重要的免疫调节作用.

Interleukin-10 （IL-10）, as a pleiotropic cytokine, was initially believed to be associated with T helper type 2 （Th2） cells. It is now known that IL-10 is produced by Thl, Thl7, regulatory T cells （Treg） , Th9, CD8 ＋ T cells,as well as B cells. In addition, the cells in innate immune system, keratinocytes, endothelial cells and tumor cells are all able to produce IL-10. IL-10 exhibits its biological functions by binding to IL-10 receptor 1 and 2,and activating Janus kinase/signal transducer and activator of transcription （ JAKSTAT） signaling pathways. IL-10 can inhibit the activation of antigen-presenting cells and downregulate the expression of costimulating molecules. Therefore,it supress the ability of it supress antigens presenting cells. IL-10 also decreases the production of inflammatory cytokines and participates the processes of immunoglobulin （Ig） class switching and immune escaping of tumor cells. IL-10 plays significant roles in the processes of many diseases such as inflammation, autoimmune diseases, tumor and graft rejection.