摘要
Objective:The authors used a meta-analytic technique to quantify the evidence of an association between maternal alcohol consumption during pregnancy and childhood acute leukemia(AL),which provided a basis for the prevention of childhood AL.Methods:Relevant literatures of maternal alcohol consumption during pregnancy were comprehensively searched and screened.Subgroup meta-analysis was conducted according to the type of leukemia.Results of research data of maternal alcohol consumption during pregnancy were tested for heterogeneity.Combined OR values and 95% CIs were statistically calculated with RevMan 4.2 software;Funnel plots were applied to conduct bias analysis for those included literatures.Results:Ten related literatures were included after data screening,4593 cases in AL group and 6157 cases in control group respectively.According to heterogeneity test result(χ2 = 16.26,P < 0.05),the combined OR values and 95% CI were calculated with random effects model,which were 1.02(0.92-1.14),Z = 0.41,P = 0.68 > 0.05,indicating that there was no significant difference between maternal alcohol consumption during pregnancy and the risk of childhood acute leukemia(AL).Subgroup analysis:for the association between maternal alcohol consumption during pregnancy and childhood acute lymphoblastic leukemia(ALL),the combined OR value and 95% CI were 0.92(0.84-1.00),Z = 1.92,P = 0.05,indicating that there was significant difference between two groups;for the association between maternal alcohol consumption during pregnancy and childhood acute non-lymphoblastic leukemia(ANLL),the combined OR values and 95% CI were 0.82(0.61-1.11),Z = 1.30,P = 0.19 > 0.05,indicating that there was no significant difference between two groups.Conclusion:Maternal alcohol consumption during pregnancy is a risk factor in childhood ALL,but not in childhood ANLL.
Objective： The authors used a meta-analytic technique to quantify the evidence of an association between ma- ternal alcohol consumption during pregnancy and childhood acute leukemia （AL）, which provided a basis for the prevention of childhood AL. Methods： Relevant literatures of maternal alcohol consumption during pregnancy were comprehensively searched and screened. Subgroup meta-analysis was conducted according to the type of leukemia. Results of research data of maternal alcohol consumption during pregnancy were tested for heterogeneity. Combined OR values and 95% CIs were statistically calculated with RevMan 4.2 software; Funnel plots were applied to conduct bias analysis for those included litera- tures. Results： Ten related literatures were included after data screening, 4593 cases in AL group and 6157 cases in control group respectively. According to heterogeneity test result （X2 = 16.26, P 〈 0.05）, the combined OR values and 95% CI were calculated with random effects model, which were 1.02 （0.92-1.14）, Z = 0.41, P = 0.68 〉 0.05, indicating that there was no significant difference between maternal alcohol consumption during pregnancy and the risk of childhood acute leukemia （AL）. Subgroup analysis： for the association between maternal alcohol consumption during pregnancy and childhood acute lympho- blastic leukemia （ALL）, the combined OR value and 95% CI were 0.92 （0.84-1.00）, Z = 1.92, P = 0.05, indicating that there was significant difference between two groups; for the association between maternal alcohol consumption during pregnancy and childhood acute non-lymphoblastic leukemia （ANLL）, the combined OR values and 95% CI were 0.82 （0.61-1.11）, Z = 1.30, P = 0.19 〉 0.05, indicating that there was no significant difference between two groups. Conclusion： Maternal alcohol consumption during pregnancy is a risk factor in childhood ALL, but not in childhood ANLL.
