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非小细胞肺癌患者循环肿瘤细胞和血管内皮生长因子的联合检测 被引量：1

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摘要 目的:探讨非小细胞肺癌(nonsmall-cell lung cancer,NSCLC)患者外周血循环肿瘤细胞和血管内皮生长因子(vascular endothelial growth factor,VEGF)联合检测的临床意义。方法:应用免疫磁珠和酶联免疫吸附技术检测60例NSCLC和40例正常肺部疾病患者术前外周血中的循环肿瘤细胞和VEGF的表达情况,分析检测结果和肿瘤生物学特性的相关性。结果:60例非小细胞患者外周血中23例检出肿瘤细胞,阳性率为38.3%;血清VEGF含量平均为(124±67)ng/L;40例正常肺部疾病患者外周血未检出肿瘤细胞;血清VEGF含量平均为(54±12)ng/L。循环肿瘤细胞阳性和阴性患者血清VEGF水平差异无显著性(P>0.05);Ⅲ期、Ⅳ期肺癌患者两项检测阳性率均高于Ⅰ期、Ⅱ期患者(P<0.05),腺癌患者两项检测阳性率均高于鳞癌患者(P<0.05)。结论:NSCLC患者外周血循环肿瘤细胞和VEGF检测均呈阳性可能提示肿瘤分期较晚,并和肿瘤类型有一定的相关性。
作者 林晓铭 程德志 蒋成榜 孙成超 何志锋 张翔
机构地区 温州医学院附属第一医院心胸外科
出处 《温州医学院学报》 CAS 2010年第4期405-407,共3页 Journal of Wenzhou Medical College
基金 温州市科技局科研基金资助项目(Y20090218)
关键词 癌 非小细胞肺 循环肿瘤细胞 血管内皮生长因子类
分类号 R655.3 [医药卫生—外科学]
  • 相关文献

参考文献10

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共引文献10

同被引文献15

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温州医学院学报
2010年 第4期

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