摘要
目的了解血必净在体外有无拮抗内毒素的作用。方法将不同浓度的血必净和标准内毒素混合后进行水浴加热,利用鲎试验(显色基质法)检测混合液中的内毒素含量。结果随着血必净浓度的增加,与阳性对照组相比,内毒素含量略有上升,但差异无统计学意义(P>0.05)。而随着水浴时间的延长,各实验组内毒素水平均呈现下降趋势,其差异无统计学意义(P>0.05)。结论血必净在体外无直接拮抗内毒素的作用。
AIM To find out whether Xuebijing has anti-endotoxin effect or not. METHODS The standard endotoxin was mixed with different concentrations of Xuebijing and heated in the water bath, then the concentration of endotoxin in these mixtures were detected by Limulus test （chromogenic substrate method）. RESULTS Compared with the positive control, level of the endotoxin was higher when the concentration of Xuebijing was added. But each concentration group of Xuebijing, together with the positive control, had lower endotoxin level in the mixtures when time went on. However, there was no significant difference among all the groups（ P 〉 0.05）. CONCLUSION Xuebijng has no antiendotoxin effect in vitro.
出处
《中国临床药学杂志》
CAS
2010年第4期239-241,共3页
Chinese Journal of Clinical Pharmacy
关键词
血必净
内毒素
鲎试验
Xuebijing
endotoxin
limulus test
