ALDH2基因多态性与冠状动脉慢血流现象的相关性

Correlation between ALDH2 polymorphism and coronary slow flow phenomenon

目的探讨ALDH2基因多态性与冠状动脉慢血流现象的关系。方法选择2006年1月至2009年6月疑诊为冠状动脉粥样硬化性心脏病而行冠状动脉造影检查的患者625例,以其中造影未见明显病变的59例为研究对象,根据TIMI帧计数法(TFC)分为慢血流组(36例)与正常血流组(23例),比较两组患者之间基本临床资料、基因型、TFC计数的差异。结果慢血流组患者的年龄水平明显低于正常血流组[(51.94±9.07)岁vs(59.36±8.81)岁,P﹤0.05],其他基本临床资料与正常血流组无统计学差异(P>0.05),而ALDH2基因的突变率显著高于正常血流组(χ2=4.584,P=0.032)。Logistic回归分析在校正年龄、吸烟、饮酒、糖尿病、高血压病及冠心病家族史等混杂因素后显示,ALDH2基因突变型是冠状动脉慢血流的独立危险因素(OR=2.322,95%CI 1.084～4.974,P=0.021)。结论 ALDH2基因突变者可能更易发生冠状动脉慢血流。

Objective To explore the correlation between aldehyde dehydrogenase 2（ALDH2） polymorphism and coronary slow flow phenomenon（CSFP）.Methods 36 patients with coronary slow flow and 23 patients with normal coronary flow were enrolled,which were defined according to the TIMI frame count（TFC）.Genotypes,TFC and clinical data of patients were determined.Results Age level of patients in the slow flow group was significantly lower than that in the normal flow group [（51.94 ± 9.07） years vs（59.36 ± 8.81） years,P ﹤ 0.05],while the other basic clin-ical data were similar between the two groups（P 0.05）.The ALDH2 gene mutation rate was higher than in the normal flow group（χ2 = 4.58,P = 0.03）.Logistic regression analysis further showed that the ALDH2 gene mutation was an independent risk factor for CSFP.Conclusion The ALDH2 gene mutation may increase the incidence of coronary slow flow phenomenon.