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吡格列酮配合生活方式干预对自发性高血压大鼠血压的影响 被引量：5

Effects of Pioglitazone combining with life style intervention on blood pressure in spontaneously hypertensive rats
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摘要 目的评价胰岛素增敏剂吡格列酮(PIO)配合生活方式干预对自发性高血压大鼠(SHR)的降压作用。方法 35只SHR随机分为3组(SHR对照组,PIO用药组及PIO配合生活方式干预组),药物添加到大鼠饮水中,生活方式干预为每日减少投食量并游泳6～15min,周期为12w,采用间接方法测量血压。结果 PIO及配合生活方式干预组大鼠饮食控制良好,游泳能力逐渐增强,无意外死亡。PIO有良好的降压效果,药物配合生活方式干预降压效果更佳,体重控制良好。结论 PIO及配合生活方式干预具有良好的降低SHR血压效果,生活方式干预可作为纠正胰岛素抵抗(IR)的方法之一应用到高血压的治疗当中。 Objective To evaluate the effects of insulin sensilizer （Pioglitazone PIO） combining with life style intervention on blood pressure in spontaneously hypertensive rats （SHRs）. Methods 35 SHRs were randomly divided into SHR control,PIO （PIO 45 mg/L in drinking water） and PIO combining with life style intervention groups. Decreasing the rat food and swimming 6~15 min/d acted as life style intervention. Results Rats in PIO combining with life style intervention group had well alimentary control and swimming ability,without accidental death. PIO had satisfactory effects on depressurization. PIO combining with life style intervention had better lowering blood pressure effect and better weight control effect. Conclusions PIO combining with life style intervention has satisfactory effects on depressurization,life style intervention could be a good method for rectifying insulin resistance and curing hypertension.
作者 王威 孔俭 李杰 陈海燕
机构地区 长春中医药大学附属医院 吉林大学第一医院干部病房
出处 《中国老年学杂志》 CAS CSCD 北大核心 2010年第14期1988-1990,共3页 Chinese Journal of Gerontology
基金 吉林省科技厅资助课题(200705165)
关键词 胰岛素增敏剂 胰岛素抵抗 生活方式 高血压 Insulin sensilizer Insulin resistance Life style Hypertension
分类号 R544.1 [医药卫生—心血管疾病]
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参考文献11

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共引文献88

同被引文献46

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引证文献5

二级引证文献2

中国老年学杂志
2010年 第14期

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