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实时PCR检测Her-2扩增状态对乳腺癌新辅助化疗治疗机理的初探

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摘要 目的检测Her-2基因拷贝量在新辅助化疗(NAC)前后的表达情况,初步探讨化疗药物对预后因子表达的调控。方法采用实时PCR方法检测28例乳腺癌初治患者在接受新辅助化疗后,乳腺癌组织中Her-2基因拷贝量的变化情况。结果新辅助化疗前Her-2基因拷贝量明显高于化疗后,但其Her-2基因拷贝量的改变与病例临床分期和化疗周期数目无关。结论新辅助化疗能使乳腺癌Her-2基因拷贝量减少,下调Her-2基因的表达,提示新辅助化疗也可能通过下调Her-2基因的表达,而改善乳腺癌患者的预后。
作者 海健 田焕 毛杰
机构地区 中南大学湘雅医院乳腺科 广东省中医院乳腺科
出处 《中国普通外科杂志》 CAS CSCD 北大核心 2010年第7期826-829,共4页 China Journal of General Surgery
基金 湖南省自然科学基金资助项目(07JJ3040)
关键词 乳腺肿瘤 新辅助化疗 REAL-TIME PCR HER-2基因
分类号 R737.9 [医药卫生—肿瘤]
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参考文献12

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二级参考文献7

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中国普通外科杂志
2010年 第7期

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