缝合材料对口腔黏膜愈合情况的影响

Oral tissue reaction to suture materials

目的:比较不同缝线及显微缝合中圆针和角针对大鼠牙龈黏膜愈合的影响。方法:将32只SD大鼠随机分为4组,在牙龈上做冠根方向的切口,分别用不同的缝线以单纯间断缝合法缝合。术后1、3、5、7 d各处死8只大鼠,拆线后取包括缝线轨迹在内的牙龈组织,固定,脱水,包埋,切片,HE染色。观察比较各组牙龈黏膜愈合情况,并将数据用秩和检验进行分析处理。结果:国产聚丙烯线和进口聚丙烯线、角针和圆针均对黏膜愈合的影响无统计学意义(P>0.05);普通丝线比显微缝线引起的组织反应要强烈(P<0.05)。结论:国产聚丙烯线和进口聚丙烯线、角针和圆针对黏膜愈合都没有明显差异;显微缝线缝合的创口比普通丝线缝合的创口愈合快。

Objective： To evaluate the inflammatory reaction induced by suture materials and suture needles in gingiva of rats.Methods： Four different suture materials were used in gingival mucosa of 32 SD rats.Eight animals were used for each test material.An incision was made in a crown-to-root alignment in gingiva,and interrupted suture were placed through the wound.Eight rats were sacrificed at the first,third,fifth,and seventh day.The sutures and surrounding tissues were retrieved en bloc,fixed,dehydrated and imbedded.Serial sections were cut and stained with haematoxylin and eosin for histopathological evaluation under a light microscope.The data were statistically analyzed by rank sum test.Results： Analysis showed that there was no statistically significant difference in tissue reaction between the imported polypropylene group and the domestic-made polypropylene group（P 0.05）.Analysis showed that the taper needle group was similar to the cutting needle group in tissue reaction（P 0.05）.Micro-suture materials has produced milder tissue reaction than silk during all experimental periods（P 0.05）.Conclusion： There are no statistically significant difference in tissue reaction between the imported polypropylene group and the domestic-made polypropylene group.There is a resemblance between the taper needle group and the cutting needle group in tissue reaction at the end periods.The wound sutured with silk may has the longer healing time than that sutured with micro-suture materials.