我国激光治疗牙本质敏感疗效的循证医学分析

Meta-analysis of the effectiveness of laser therapy in the treatment of dentin hypersensitivity in China

目的:评价我国激光治疗牙本质敏感的疗效。方法:采用Cochrane系统评价的方法,计算机和手工方法检索1989～2009年国内有关激光治疗牙本质敏感的随机对照临床研究。在严格筛选资料和质量评价的基础上,采用RevMan 5.0.1软件对纳入的研究进行Meta分析。结果:共检索到114篇相关文献,最终有9篇文献符合纳入标准。分析结果显示:除了激光治疗牙本质敏感的即刻疗效的数据可以合并外,各研究间其他时期的疗效均存在统计学异质性,数据无法合并,只能采用描述性分析。激光治疗牙本质敏感的即刻疗效优于对照组,差异有统计学意义[OR=3.83,95%CI(2.86,5.12)],其他时期疗效均有优于对照组的趋势。结论:激光治疗牙本质敏感疗效较好。但由于本研究中部分文献的质量不高,上述结论还需开展更多大样本的、设计严谨的随机对照研究来验证。

Objective： To evaluate the effectiveness of laser therapy in the treatment of dentin hypersensitivity in China.Methods： The Cochrane reviewer＇s handbook was followed.Domestic published articles from 1989～2009 were selected by computer and handsearch.All these retrieved study were clinical control trials related to laser therapy in the treatment of dentin hypersensitivity.The quality of included studies was critically evaluated and data were analyzed by the RevMan 5.0.1 software.Results： A tota1 of 114 articles were selected,but only 9 were included.The results showed that： although the data of immediate efficiency of laser treating dentin hypersensitivity could be combined,significant heterogeneity was found when the other studies＇ data were pooled.So the data could not be merged,only the descriptive analysis could be used.The immediate efficiency for the treatment of dentine hypersensitivity using lasers was higher than the control group,the difference was statistically significant[OR=3.83,95%CI（2.86,5.12）],other period of efficacy had a trend which was superior to the control group.Conclusion： Comparing with the control group,the desensitizing of dentin hypersensitivity with laser is more effective.However,because the literature quality of this study is not high,the above conclusion needs to be verified by larger sample-size,rigorously designed,randomized controlled clinical trials.