干细胞及神经相关因子对运动性周围神经损伤再生的影响

Stem cells and nerve-related factors effects on exercise-induced peripheral nerve injury regeneration

背景:当前干细胞技术在心脑血管病、中枢神经损伤和外周神经损伤等都具有十分重要的作用。但是在对运动引起周围神经损伤方面的研究还处于基础阶段。目的:论文旨在研究当前干细胞技术运用于运动性周围神经损伤的研究现状,为运动性周围神经损伤的康复奠定科学基础。方法:通过计算机检索PubMed数据库1991-01/2010-01的相关文献,文献所述内容与干细胞和运动性周围神经损伤的研究密切相关。共选取26篇文献,结果与结论:运动训练中经常出现所谓的周围神经损伤性疾病,而依靠干细胞移植和诱导分化技术可以促进周围神经损伤的再生,且对促进运动训练中周围神经损伤的防治具有十分重要的作用。但由于目前尚处于基础研究阶段,还有待进一步的深入研究。

BACKGROUND：Current stem cell technology in heart and brain diseases,central nervous system damage and peripheral nerve injury plays an important role.However,the exercise-induced peripheral nerve injury research is still in the basic stage.OBJECTIVE：To study the current stem cell technologies used in exercise-induced regeneration of peripheral nerve injury,in order to lay the scientific basis of rehabilitation of exercise-induced peripheral nerve injury.METHODS：We searched PubMed database by computer for related literatures published from January 1991 to January 2010.The literature content was closely related to the study of stem cells and exercise-induced peripheral nerve injury.A total of 26 documents were selected.RESULTS AND CONCLUSION：Diseases of peripheral nerve injury often occur during exercise training,while stem cell transplantation and induction differentiation technologies can facilitate the regeneration of peripheral nerve injury,and plays an important role in the promotion of sports training in the prevention and treatment of peripheral nerve injury.However,it is still in the basic research stage,and requires further studies.