输卵管避孕及皮下埋植缓释避孕药物的应用

Oviductal contraception and subcutaneous implantation of slow-release contraceptive drugs

目的:探讨新型可复性输卵管节育器的避孕效果以及皮下埋植缓控释避孕药引起的不良反应发生情况。方法:由第一作者应用计算机检索万方数据库(http://med.wanfangdata.com/)中与输卵管避孕和皮下埋植缓控释避孕药有关的文献,检索时限1998-01/2010-04。检索词:输卵管节育器;皮下埋植;缓控释避孕药。共入选23篇文献进一步分析。结果:镍钛合金材料、聚乙烯等高分子材料的输卵管节育器是安全的,有较好的组织相容性,且具有放置顺利、定位良好、取出自如等优点。皮下埋植避孕是一种高效、长效、安全、简便、可逆性高的深为育龄妇女欢迎的避孕方法,取出时断裂少,值得推广使用,但使用中出现的不良反应值得深入研究。结论:随着新材料技术的不断发展,希望研制出性能优良、不良反应少的避孕系统,使其更好地应用于临床。

OBJECTIVE：To explore the contraceptive effect of new reversible contraceptive device on oviduct and side effects caused by subcutaneous implants of controlled-release contraceptive drugs.METHODS：A computer search was performed by the first author among Wanfang database（http：//med.wanfangdata.com/）for articles about oviductal contraception and subcutaneous implantation of controlled-release contraceptive drugs.The retrieval time was 1998-01/2010-04.Key words are contraceptive device on oviduct;subcutaneous implants;slow-release contraceptive drugs.Totally 23 literatures were selected for further analysis.RESULTS：The contraceptive device on oviduct made of nickel titanium alloy,polyethylene and other polymer materials,are safe and well histocompatible,present with a smooth placing,well positioned and easy dislodge.Subcutaneous implants for contraception is an efficient,long-lasting,safe,simple,reversible method,which is deeply welcomed by the women at reproductive age,with less breakage upon dislodging.However,further studies are needed to determine side effects.CONCLUSION：With the continuous development of new materials and techniques,it is an increasing requirement to produce excellent contraceptive system,with less side effects,so as to achieve better outcome in clinical application.