泌尿系统组织工程支架材料的发展与应用

Development and application of tissue engineered scaffold materials in urinary system

背景:应用组织工程方法进行膀胱、尿道、输尿管以及阴茎海绵体等各类泌尿器官重建的报道逐年增加,其中各类重建器官中支架材料的应用显得十分重要。目的:结合近年来的相关文献,对组织工程支架材料在泌尿系统修复和重建中的应用进行总结。方法:由第一作者应用计算机检索Pubmed2003-01/2009-11相关文章,检索词为"tissue engineering,biomaterials, urethra,bladder,urology",并限定语言种类为"English";同时检索中国期刊数据库2003-01/2009-11的相关文章,检索词为"组织工程,支架材料,尿道,膀胱,尿路",并限定文章语言种类为中文。选择文章内容与组织工程支架在泌尿系统中的应用相关,同一领域文献则选择近期发表或发表在权威杂志文章。结果与结论:利用组织工程生物材料作为支架进行组织或器官修复与重建是目前泌尿系统组织工程研究的主要领域,各种天然、人工及复合材料相继用于动物实验或临床应用,尤其最近纳米技术的发展及应用为组织工程又开辟了一条新的途径,因此根据组织特性选取理化性质及超微结构相似的替代材料将是泌尿系统组织工程支架材料发展的方向。

BACKGROUND：There is an increasing number of reports addressing the reconstruction of various urinary organs,such as the bladder,urethra,ureter and corpus cavernosum penis,by using tissue engineering approaches,and scaffold materials have great significance in the reconstruction.OBJECTIVE：To summarize the current development of scaffold materials in tissue engineering repair and reconstruction for urinary organs based on the recent literatures.METHODS：An online search was conducted in Pubmed database and CNKI database to identify the articles related to scaffolds biomaterials in urology published from January 2003 to November 2009 using the key words of＂tissue engineering,biomaterials,urethra,bladder,urology＂in English and＂tissue engineering,scaffolds,urethra,bladder,urinary tract＂in Chinese.Inclusive criterion：The contents of articles were related to the application of tissue engineered scaffolds in urology,those published recently or in authorized journals are preferred as for the same field.RESULTS AND CONCLUSION：Using biological materials as tissue engineering scaffold for organ repair and reconstruction is currently the main areas of urinary system tissue engineering research,a variety of natural,artificial and composite materials have used in animal experiments or clinical applications,in particular the recent development and application of nanotechnology has opened up a new way for tissue engineering,therefore,it is a promising direction of urinary system tissue engineering scaffold materials that selecting alternative materials of similar physico-chemical property and ultrastructure.