银杏叶提取物对脑缺血再灌注损伤的保护作用

Ginkgo biloba extract protects brain from ischemia/reperfusion injuries

银杏叶提取物(Ginkgo biloba extract,GBE)是近代植物药中被研究开发,用于防治缺血性脑血管病的热点药物之一。研究发现,GBE对脑缺血再灌注损伤具有保护效应,其作用机制涉及抗氧化、清除自由基、抑制兴奋性氨基酸的释放、抗炎及抑制神经细胞凋亡等多个方面。文中就银杏叶提取物在对抗脑缺血再灌注损伤中的作用及机制作一综述。

Ginkgo biloba extract（GBE） is one of the hot spots of drugs extracted from plants recently;it protects brain from ischemia/reperfusion injuries.The mechanism of protective effects includes antioxidation,free radicals clearance,inhibiting the release of excitatory amino acid,anti-inflammation,inhibiting neural apoptosis and other biological effects.