摘要
检测天津地区119例慢性肝病患者HBV、HCV标志,并对其中28例HCVRNA阳性血清进行基因分型。结果,HBV感染率明显高于HCV感染率(P<0.05),肝癌患者中HBV、HCV重叠感染率明显高于慢性肝炎组(P<0.05);各组均以HCVⅡ型为主。提示天津地区慢性肝病目前仍以HBV感染为主;HBV、HCV重叠感染对肝癌的发生似有相加作用;HCVⅡ型感染在天津地区HCV相关性慢性肝病中可能起主要作用。
WedetectedmarkersofHBVandHCVof119patientswithchronicliverdisease28HCVRNApositiveserawereanalyzedbyRFLPThedateshowedtheinfectionrateofHBVwassignificantlyhigherthanthatofHCV,( PWTBZ<005);superinfectionrateofHBVandHCVofHepatocellularCarcinomawassignificantlyhigherthanthatofchronichepatitis,( P <005);superinfectionrateofHBVandHCVofHepatocellularCarcinomawassignificantlyhigherthanthatofchronichepatitis,( P <005);HCVgenotypesofallgroupsweremainlyoftypeTheseresultsindicatedHBVwasstillthemainpathogenicfactorofchronicliverdiseaseinTianjinarea,superinfectionmayacceleratetheprogressoflivercancer;HCVtypeappearedtoplayamainroleinthedevelopmentofHCVassociatedchronicliverdisease
出处
《临床肝胆病杂志》
CAS
北大核心
1999年第1期34-36,共3页
Journal of Clinical Hepatology