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睫状神经营养因子对视神经损伤的修复作用 被引量：1

The repair effect of ciliary neurotrophic factor on the injury of optic nerve
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摘要 视神经损伤后,视网膜神经节细胞进行性损害,轴突变性坏死,再生困难。睫状神经营养因子是一种非靶源性神经营养因子,在视网膜神经节细胞的生长发育中起重要调控作用,主要表现在对损伤的视网膜神经节细胞有促进存活及轴突再生的作用。 Retina1 ganglion cells will be damaged constantly with axon degeneration and even necrosis and difficult regeneration of axons after the optic nerve is injuried. Ciliary neurotrophic factor is a non-target-derived neurotrophic factor, plays an important role in regulating the growth and development of retinal ganglion cells, mostly and in promoting the repair of the injured retinal ganglion cells and axonal regeneration.
作者 黄靓 马海英 孔力
机构地区 大连医科大学 大连医科大学组织学与胚胎学教研室
出处 《解剖科学进展》 CAS 2010年第4期360-363,共4页 Progress of Anatomical Sciences
基金 国家自然科学基金资助项目(No30850001) 辽宁省自然科学基金资助项目(No20072167)
关键词 睫状神经营养因子 视神经损伤 修复作用 视网膜神经节细胞 靶源性神经营养因子 轴突再生 进行性损害 变性坏死
分类号 R339.146 [医药卫生—人体生理学]
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参考文献30

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二级参考文献62

共引文献23

同被引文献15

  • 1杨小丽,张皙,顾青,张喜梅,孙晓东.视神经损伤时视网膜睫状神经营养因子受体的表达[J].眼科研究,2005,23(2):195-197. 被引量：7
  • 2Hubel DH,Wiesel TN. Early exploration of the visual cortex[J]. Neuron, 1998,20 : 401-412.
  • 3Hellstrom M, Harvey AR. Retinal ganglion cell gene therapy and visual system repair[J]. Curr Gene Ther,2011,11 : 116-131.
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  • 5Blanehard J,Chohan MO, Li B, et al. Beneficial effect of a CNTF tetrapeptide on adult hippocampal neurogenesis,neuronal plasticity and spatial memory in mice [J]. J Alzheimers Dis,2010,21 : 1185 - 1195.
  • 6Garcia P, Youssef I, Utvik JK, et al. Ciliary neurotrophic tactor cell-based [ delivery prevents synaptic impairment and improves memory in mouse models of Alzheimer' s disease[J]. J Neurosci,2010,30:7516-7527.
  • 7Cao J, Sun C ,Zhao H,et al. The use of laminin modified linear ordered collagen scaffolds loaded with laminin-binding ciliary neurotrophic factor for sciatic nerve regeneration in rats [ J ]. Biomaterials, 2011,32 : 3939-3948.
  • 8Chen J,Chu YF,Chen JM,et al. Synergistic effects of NGF,CNTF and GDNF on functional recovery following sciatic nerve injury in rats[ J]. Adv Med Sci,2010,55:32-42.
  • 9Simon CM, Jablonka S, Ruiz R, et al. Ciliary neurotrophic factor- induced sprouting preserves motor function in a mouse model of mild spinal muscular atrophy[ J]. Hum Mol Genet,2010,19 : 973-986.
  • 10Pease ME,Zack DJ, Berlinicke C, et al. Effect of CNTF on retinal gangliort cell survival in experimental glaucoma[ J ]. Invest Ophthalmol Vis Sci ,2009,50 : 2194-2200.

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解剖科学进展
2010年 第4期

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