数值模拟前庭系统膜迷路的生物力学响应

Numerically simulating the biomechanical response to membranous labyrinth in the vestibular system

目的研究平衡感受器嵴顶对旋转椅试验的生物力学响应,为前庭系统功能状态的评估提供定量分析的平台。方法基于健康志愿者右侧颞骨完整的组织切片数据进行三维几何重建。运用拉格朗日法数值模拟头前倾30毅、频率0.8Hz、幅度依40毅的正弦摆动旋转椅试验中受试者前庭系统膜迷路的生物力学响应。结果右耳水平半规管嵴顶峰值位移为54.2μm,后规管嵴顶峰值位移为15.9μm;右耳前半规管嵴顶峰值位移为43.7μm,但是左右耳响应相同,对眼球运动的作用相互抵消;向右旋转,右耳水平半规管壶腹嵴嵴顶法向位移从管侧偏向椭圆囊侧,左耳水平半规管壶腹嵴嵴顶法向位移从椭圆囊侧偏向管侧,向左旋转时则相反。结论数值模拟得到的嵴顶的生物力学响应符合Flourens定律和Ewald定律。

Objective To study the biomechanical response to cupulae partition of statoreceptor in the rotational chair test and to provide a quantitive platform for vestibular system assessment.Method Based on the histological slides from the right temporal bones from a healthy volunteer,a three-dimensional geometry of membranous labyrinth in the vestibular system was reconstructed.The biomechanical response of the volunteer to sinusoidal rotation chair test（0.8 Hz,±40°） with the head pitch 30° was numerically simulated by the Lagrangian method.Results The maximum displacement of cupula partition in the right horizontal semicircular canal is 54.2 μm,and 15.9 μm in the posterior semicircular canal as well as 43.7 μm in the anterior semicircular canal.However,the displacement response in the anterior semicircular canal is identical on both ears,and it would counteract the eye movement.Secondly,the normal displacement in the right semicircular canal deflect from the side of canal to the side of utricle,while in the left semicircular canal,it deflect from the side of utricle to the side of canal when the chair rotated to the right,and it is opposite when the chair rotate to the left.Conclusions The biomechanical response to cupulae partition by this numerical simulation is in accordance with Flourens law and Ewald laws.