巩膜及巩膜成纤维细胞的生物力学研究进展

Advances in biomechanical study of sclera and scleral fibroblasts

巩膜在维持眼球结构和功能等方面起着重要的作用。巩膜成纤维细胞胞外基质的代谢、细胞因子的表达及自身生物力学性质等决定巩膜的生物学和生物力学性质。在近视的发生及治疗过程中,伴随有巩膜及巩膜成纤维细胞的力学-生物学特性的变化。从力学-生物学耦合角度对巩膜及巩膜成纤维细胞进行生物力学研究,能够深入、全面地揭示视觉器官的生理功能、病理变化及相关治疗机理。本文对巩膜及巩膜成纤维细胞的生物力学研究进行了综述和讨论。

Sclera plays an very important role in maintenance of eyeball structure and its functions.The biological and biomechanical properties of sclera is determined by the extra cellular matrix metabolism,the cytokine expression and its own biomechanical properties of scleral fibroblasts.Lots of biological and biomechanical changes in sclera and scleral fibroblasts are the concomitants in the process of myopic development and therapy.The biomechanical studies on sclera and scleral fibroblasts by Mechanics-Biology coupling will enable to reveal the physiological function,pathological change and therapeutic mechanism of ocular organ and in this review,such biomechanical studies about sclera and scleral fibroblasts were summarized and discussed.