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血管内皮保护在防治动脉粥样硬化中的作用 被引量：3

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摘要 血管内皮在保持血管稳定方面发挥着重要的作用^[1]，内皮功能随增龄受损并且动脉弹性减低与内皮功能障碍有关^[2]。血管内皮功能障碍不仅是动脉粥样硬化的始动因素，也是心血管危险因子作用的靶器官，因此，保护血管内皮功能成为治疗心血管疾病的新靶点之一。
作者 陶军 张小宇
机构地区 中山大学附属第一医院心血管内科
出处 《中华老年医学杂志》 CAS CSCD 北大核心 2010年第7期530-531,共2页 Chinese Journal of Geriatrics
关键词 血管内皮保护 动脉粥样硬化 血管内皮功能障碍 保护血管内皮功能 心血管危险因子 防治 心血管疾病 动脉弹性
分类号 R543 [医药卫生—心血管疾病]
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参考文献7

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同被引文献44

  • 1Tsuchikura S, Shoji T, Kimoto E, et al. Brachial ankle pulse wave velocity as an index of central arterial stiffness. J Atheroscler Thromb, 2010, 17: 658-665.
  • 2Shin JY, Lee HR, Lee DC. Arterial stiffness and cardiovascular events: The Framingham Heart Study. Circulation,2010,121 : 505-511.
  • 3Chen X,Li Y, Sheng CS, et al. Association of serum uric acid with aortic stiffness and pressure in a Chinese workplace setting. Am J Hypertens, 2010, 23:387-392.
  • 4Tedesco MA,Natale F,Di Salvo G, et al. Effects of coexisting hypertension and type II diabetes mellitus on arterial stiffness. J Hum Hyperten,2004,18:469- 473.
  • 5Shin JY, Lee HR, Lee DC. Increased arterial stiffness in healthy subjects with high-normal glucose levels and in subjects with pre diabetes. Cardiovasc Diabetol, 2011,15: 10-30.
  • 6Ghiadoni L, Penno G,Giannarelli C, et al. Metabolic syndrome and vascular alterations in normotensive subjects at risk of diabetes mellitus. Hypertension, 2008,51 : 440-445.
  • 7Nakhai-Pour HR, Grobbee DE, Bots ML, et al. C- reactive protein and aortic stiffness and wave reflection in middle-aged and elderly men from the community. J Hum Hypertens,2007,21 : 949-955.
  • 8Lakatta EG. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part Ⅲ: cellular and molecular clues to heart and arterial aging. Circulation, 2003,107 : 490-497.
  • 9FruehartJC, Sacks F, Hermans MP, et al. The residual risk reduction initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia. Am J Cardiol, 2008,102 : 1-34.
  • 10Salvi P,Safar ME, Labat C,et al. Heart disease and changes in pulse wave velocity and pulse pressure amplification in the elderly over 80 years: the PARTAGE Study. J Hypertens, 2010, 28: 2127-2733.

引证文献3

二级引证文献25

中华老年医学杂志
2010年 第7期

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