老年人空腹血清生长激素释放肽水平及其与代谢异常的关系

Analysis on serum ghrelin levels and its correlation with metabolic disorders in elderly Chinese

目的 检测老年人血清中生长激素释放肽（ghrelin）的水平,分析其与肥胖、年龄和各种代谢异常的关系.方法 抽样选取60岁以上无吸烟饮酒嗜好、无严重的糖尿病并发症和冠心病及肝肾功能正常男性健康体检者109例,检测空腹血清ghrelin浓度,与肥胖等代谢异常进行横断面研究.结果 老年男性体质指数正常者ghrelin浓度为（823.6±410.4）ng/L,超重和肥胖者显著下降,分别为（442.4±171.1）ng/L和（434.6±177.7）ng/L.随着代谢异常组分的增加,满足3个及以上代谢异常者血清ghrelin水平为（420.8±165.9）ng/L,较无代谢异常者（725.5±407.8）ng/L和1项异常者（575.4±320.4）ng/L显著下降.单因素相关分析显示,ghrelin水平与体质指数、三酰甘油和血尿酸呈负相关（r=-0.359、-0.243、-0.189）,而与年龄、血压、空腹血糖和胰岛素水平不相关.多元逐步回归分析显示,仅体质指数对ghrelin的影响具有统计学意义（β=-0.386）.结论 老年男性空腹血清ghrelin与体质指数密切相关,随着代谢异常数目的增加,ghrelin水平显著降低.

Objective To measure serum ghrelin level in elderly Chinese, and investigate the relationship of the serum ghrelin level with age, obesity and other metabolic disorders. Methods A total of 109 men aged over 60 years without history of smoking and alcohol consumption from health examination were enrolled in this study. Subjects were excluded if they had serious diabetic complications, coronary artery disease and hepatic or renal dysfunction. A cross sectional study was made on ghrelin level and the correlated metabolic disorders. Results Compared with ghrelin level in subjects with normal BMI [（823. 57±410.40） ng/L], the ghrelin level was significantly decreased in overweight and obese elderly male, [（442.42 ± 171.10） ng/L and （434.64 ± 177.65） ng/L respectively]. ghrelin was significantly lower in subjects with three or more metabolic disorders （420.84±165.91） ng/L than in those with less disorder. Single factor analysis showed ghrelin was inversely associated with BMI, TG and uric acid （r=-0.359,-0.243,-0.189）, but it was not associated with age, blood pressure, fasting glucose and insulin levels. Multivariate analysis revealed only BMI significantly affected the level of ghrelin （β =-0.386）. Conclusions BMI is closely associated with ghrelin in elderly male,ghrelin is significantly lower with increased number of metabolic disorders.