新疆墨玉县维吾尔族成人牙周炎与慢性肾脏病患病率的流行病学研究

Epidemiologic study on the relationship between periodontitis and chronic kidney disease among Uygur adults in Moyu county, Xinjiang

目的探讨维吾尔族成人牙周炎与慢性肾脏病（CKD）患病率的关系。方法采用分层容量随机抽样方法，从墨玉县364个村抽取15个村18岁以上维吾尔族成人1650人，进行问卷调查、慢性肾损伤指标检测、相关危险因素调查及口腔检查。依据慢性牙周炎的诊断标准，将调查对象分为牙周炎组和非牙周炎组，其中牙周炎组按其严重程度进一步分为轻度牙周炎组、中度牙周炎组和重度牙周炎组。结果在资料完整的1415人中，慢性牙周炎患病率为65．2％（95％（21：65．0～65．4），CKD患病率为5．2％（95％CI：5．1～5．3），蛋白尿的患病率为4．2％（95％CI：4．1～4．3），慢性肾功能不全的患病率为1.3％（95％CI：1．3～1．4）。牙周炎组和非牙周炎组CKD患病率差异有统计学意义（6．4％比2．9％，X^2=7．841，P=0．005）。单因素Logistic回归分析显示重度牙周炎为CKD的危险因素（OR=3．2，95％CI：2．0～5．2）。多因素Logistic回归亦显示重度牙周炎是CKD发生的独立危险因素（OR=1．9，95％CI：1．1～3．3）。结论新疆农村维吾尔族成人是牙周炎的高发人群。牙周炎人群CKD患病率明显高于非牙周炎人群。重度牙周炎是CKD的独立危险因素。

Objective To study the relationship between periodontitis and chronic kidney disease （CKD） among Uygur adults of Xinjiang. Methods Data of 1650 Uygur adult residents （age〉18 years） in the Moyu county, Xinjiang were analyzed. The subjects were sampled randomly with stratify capacity from 15 villages among 364 villages. All the subjects received the questionnaire and the oral examination. The markers and risk factors of chronic renal injury were inspected. The subjects were categorized as periodontitis group and non-periodontitis group according to chronic periodontitis diagnostic criteria. The periodontitis group was further divided into mild, moderate and severe periodontitis. Results The data of 1415 subjects were completed. The prevalence of chronic periodontitis was 65.2% （95%C1：65.0-65.4）. The prevalence of CKD was 5.2% （95%CI：5.1-5.3）. Albuminuria was found in 4.2% （95%CI：4.1-4.3） of subjects. 1.3% （95%CI：1.3-1.4） of individuals had renal insufficiency. In periodontitis group, the prevalence of CKD was 6.4%, which was higher than that in non-periodontitis group 2.9% （x^2=7.841 ,P=0.005）. Univariate regression analysis showed that severe periodontitis was risk factor of CKD （OR=3.2,95% CI：2.0-5.2）. Multivariate logistic regression analysis showed that severe periodontitis was independently associated with CKD （OR=1.9, 95%CI：1.1-3.3）. Conclusions In Uygur adults of rural area of Xinjiang, the prevalence of CKD is higher in periodontitis group as compared to non-periodontitis group. Severe periodontitis is an independent risk factor of CKD.