我国人群中抗b 型流感嗜血杆菌多糖抗体水平的调查

The investigation of natural antibody level to Haemophilus influenzae type b polysaccharide in China

目的 调查中国人群中抗流感嗜血杆菌多糖（ Ｈｉｂ － Ｐ Ｒ Ｐ） 自然抗体水平，为合理使用 Ｈｉｂ 菌苗提供资料。方法 从７ 个省市收集１ ５９６ 份不同年龄组健康人群血清标本，用放射免疫方法检测抗 Ｈｉｂ － Ｐ Ｒ Ｐ 自然抗体水平。结果 甘肃、贵州、江西等地５ 岁以下婴幼儿平均抗体水平＜０ ．１μｇ／ ｍｌ，上海、广西、黑龙江等地相对较高。脐带血平均抗体含量为０ ．３６μｇ／ ｍｌ，６ 月～５ 岁儿童平均抗体含量为＜ ０ ．１５μｇ／ｍｌ，６ 岁至成人则达１ ～１ ．５μｇ／ｍｌ。结论 中国人群对 Ｈｉｂ 疾病的群体免疫力不高。６ 月～５ 岁儿童自然抗体水平最低，为 Ｈｉｂ 疾病的高危人群。

Objective Investigation of natural antibody level to Haemophilus influenzae type b polysaccharide in China. Methods 1 596 sera samples from cord (55 sera), infants ( 1 383 sera), children (66 sera), adult (52 sera) and elderly (40 sera) were collected from different provinces and the natural antibody level to PRP was measured with a standardized radio immunoassay 125 I-labeled PRP. Results Antibody level of infants under 5 year olds in different provinces was different. Levels of infants from Gansu, Guizhou, Jiangxi province were lower (≤0.07μg/ml) than from Shanhai, Guangxi and Heilognjiang. Comparison of antibody levels with different age groups showed that infants aged 6 months to 5 years having the lowest antibody level (<0.15μg/ml). The level increased rapidly during 6- 10 years of age (≥1.0μg/ml). The levels of adults and elderly were about 1-1.5μg/ml. Conclusion General immunity against Hib disease were low in Chinese population. Children aged 6 months to 5 years old with lowest natural antibody level to PRP were the population under high risk .