人表皮生长因子含量变化与肝病关系的研究

Study on variations of serum h-EGF levels and it′s relation with liver disease

目的研究ｈＥＧＦ含量变化在肝病中的作用和意义。方法采用放免法测定１１０例各型肝病患者血浆ｈＥＧＦ的含量并结合临床资料进行统计分析。结果各肝病组血浆ｈＥＧＦ含量均较对照组明显增高（Ｐ＜０．０１），组间比较除慢性肝炎轻度组与急性肝炎组无显著性差异外，其它各组间均呈极显著性差异。

Objectives To study the action and significance of serum huncan epidermal growth factor(h-EGF) in patients with liver disease.Methods Radioimmunoassay (RIA) was performed in llo patients with varions types of liver disease to determine the serum levels of h-EGF and the clata were statistically analyzed combined with clinic information.Results The serum h-EGF contents in patients with liver disease increased slgnifieantly as compared with normal subjects( P <0.01).The difference between two groups of all types of liver disease was sigrificant except between the groups of mild chronis hepatitis and acute hepatitis.Conclusion The rariations of serum h-EGF livets in patients with liver disease has some clinical significance in evaluating the severe degrece of liver injury and the prognosis of liver disease.