自体成体干细胞在肝纤维化中的作用

Role of autologous adult stem cells in liver firbrosis

肝纤维化是机体针对各种慢性肝损伤所引起的一种损伤修复反应,其不断发展最终将导致肝硬化,而一旦发展为肝硬化,则惟一有效的治疗方法将是肝移植.近年来,许多学者采取多种方法试图来治疗肝纤维化,以防其发展为肝硬化.自体成体干细胞因具有多向分化能力及移植后不会发生排斥反应等优点,成为众多肝纤维化治疗方法中的研究热点,并取得了显著进展.

Hepatic fibrosis is a wound-healing re-sponse to all kinds of chronic liver injury, which if persistent can lead to cirrhosis. Once develops to cirrhosis, the only ef-fective therapy will be liver transplantation. In recent years,many scholars have taken all kinds of methods to try to pre-vent liver fibrosis developing to cirrhosis. As auto adult stem cell possesses multi-directional differentiation and none reject reaction advantages, it has become the study hotspot of nu-merous researches for hepatic fibrosis therapy and acquired significant progression.