Mohnarin 2008年度报告:华北地区革兰阳性菌临床感染特征及结果分析

2008 Mohnarin report:Characteristics and resistance analysis of Gram positive bacteria clinical infections in north China

目的调查华北地区细菌感染患者革兰阳性菌的耐药状况。方法在统一方案和统一标准前提下,收集包括北京、天津、河北、内蒙古和山西5个地区临床分离革兰阳性菌药物敏感性结果,用WHONET5.4软件进行数据分析。结果自2008年1月至2008年12月共收集革兰阳性菌11630株,包括葡萄球菌属7551株,肠球菌2933株,链球菌867株,其它革兰阳性菌289株。耐甲氧西林金黄色葡萄球菌(MRSA)和凝固酶阴性耐甲氧西林葡萄球菌(MRCNS)的比例分别为62.8%和81.5%。肺炎链球菌对青霉素的不敏感率为38.8%。粪肠球菌和屎肠球菌万古霉素耐药率分别为2.6%和6.4%。结论革兰阳性菌耐药呈现明显上升趋势,临床应采取积极措施,合理用药,以减少耐药发生。

Objective To investigate Gram positive bacterial distribution and resistace in north China in 2008. Methods Bacteria were collected from Bejing, Tianjin, Hebei, Neimeng and Shanxi. Susceptibility testing was carried out according to an agreed protocol and standard.The results were analyzed by WHONET 5.4. Results Totally, 11630 Gram positive bacteria were collected during the survey period, which included Staphylococcus 7551 strains, enterococci 2,933 strains, Streptococcus 867 strains and other Gram positive bacteria 289 strains. 62.8% and 81.5% of Staphylococcus aureus and coagulase-negtive staphylococci were methicillin-resistant （MRS）, respectively. The detection rate of penicillin non-susceptible Streptococcus pneumoniae （PNSSP） was 38.8%. The resistance rates of Enterococcus faecalis and Enterococcus faecium to vancomycin （VILE） were 2.6% and 6.4%, respectively. Conclusion The antimicrobial resistance of Gram positive bacteria was increasing. It was very important to reasonable application antibiotics and prevent the dissemination and outbreak of resistant bacteria.