P311和整合素β4结合蛋白在非小细胞肺癌中的表达及意义

Expression and significance of P311 and ITGB4BP in non-small cell lung cancer

目的 探讨P311和整合素β4结合蛋白（ITGB4BP）在非小细胞肺癌（NSCLC）中的表达及意义.方法 80例NSCLC石蜡标本制成组织芯片,采用链菌素亲生物素-过氧化物酶法（SP）检测F311和ITGB4BP的表达情况,应用SPSS 13.0软件进行统计分析.结果 P311和ITGB4BP在NSCLC中的阳性表达率分别为77.5%（62/80）和82.5%（66/80）,P311和ITGIMBP表达均阳性者占73.8%（59/80）,一致率为87.5%,具有显著一致性（Kappa=0.611,P〈0.001）.结论 NSCLC中可能存在一条新信号途径P311-ITGB4BP,且可能具有调节肺癌细胞迁移的作用.

Objective Thee aim of this study was to investige the expression and significance of P311 and ITGB4BP in non-small cell lung cancer （NSCLC）. Methods Tissue microarrays were prepared from 80 NSCLC specimens and examined by immunohistochemistry. Results The positive rates of P311 and ITGB4BP expression were 77.5% （62/80） and 82.5% （66/80）, respectively. The double positive expression rate was 73.8% （59/80）. The consistency rate was 87.5%, and there was a significant consistency between P311 and ITGB4BP expressions （Kappa = 0.611,P〈0.001）. Conclusion There may be a new signaling pathway P311-ITGB4BP in NSCLC, and it may regulate the lung cancer cell migration.