糖耐量异常缺血性中风患者的阴阳类证特点及颈动脉内中膜厚度临床研究

Investigation of Yin and Yang Series-syndromes and Carotid Intima-media Thickness in Ischemic Stroke Patients with Impaired Glucose Tolerance

目的:观察糖耐量异常(IGT)缺血性中风患者阴阳类证分布、颈动脉内中膜厚度(IMT)及其神经功能缺损程度,探讨IGT缺血性中风的发病特点。方法:将117例患者根据口服葡萄糖耐量试验结果分为正常血糖(NGT)组、IGT组和糖尿病(DM)组,每组患者辨证分为阳类证与阴类证。检测患者的神经功能评分(NIHSS)、血糖及颈动脉IMT。结果:IGT组、DM组阳类证分别占54.3%和57.9%,均明显高于NGT组(31.8%),差异均有显著性意义(P<0.05)。IGT组、DM组NIHSS评分与IMT均明显高(厚)于NGT组,差异有显著性或非常显著性意义(P<0.05,P<0.01)。IGT组阳类证NIHSS评分明显高于阴类证,差异有非常显著性意义(P<0.01)。DM组NIHSS评分与IMT虽然高(厚)于IGT组,但2组比较,差异无显著性意义(P>0.05)。结论:IGT合并缺血性中风患者以阳类证为主,其IMT明显增厚,神经功能缺损程度较为严重。

Objective: To investigate the distribution of yin and yang series-syndromes,intima-media thickness (IMT),and neurologic impairment in ischemic stroke patients with impaired glucose tolerance (IGT).Methods: Based on the results of oral glucose tolerance test,117 qualified patients were divided into normal glucose tolerance (NGT) group,IGT group and diabetes mellitus (DM) group. All of the patients were classified into yin series-syndrome or yang series-syndrome according to the symptoms and signs. The neurologic score evaluated by the National Institutes of Health Stroke Scale (NIHSS),blood glucose (BG) and IMT were examined. Results: The patients with yang series-syndrome accounted for 54. 3% in IGT group and 57. 9% in DM group,higher than 31. 8% in NGT group,the difference being significant between the two groups ( P < 0. 05).NIHSS score in IGT group and DM group was higher than that in NGT group ( P < 0. 05 or P < 0. 01 ). NIHSS score in IGT patients with yang series-syndrome was obviously higher than that in IGT patients with yin series-syndrome ( P < 0. 01). The difference of NIHSS score was insignificant between DM group and IGT group ( P > 0. 05).Conclusion: In ischemic stroke patients with IGT,Yang series-syndrome is dominant,IMT is increased and neurologic impairment is serious.