283例结节性红斑临床分析

Clinical Analysis of 283 Patients with Erythema Nodosum

目的探讨结节性红斑的病因、临床特点及治疗方法。方法对1999年1月2009年12月收治的283例结节性红斑患者进行分析。结果此病多见于中青年患者,男:女比例为1∶6.8。其中结核杆菌感染94例(33.22%),链球菌感染25例(22.26%);白塞病5例(1.77%),干燥综合征2例(0.71%),系统性红斑狼疮7例(2.47%),类风湿性关节炎5例(1.77%);淋巴瘤2例(0.71%);病因不明66例(23.32%)。治疗结果较好。结论结节性红斑为多因素疾病,与感染性疾病最为密切,多见于结核杆菌及链球菌感染。治疗应积极驱除病因和对症治疗。

Objective To analyze the etiology,clinical features and treatment of the erythema nodosum （EN）. Methods A total of 283 patients with a diagnosis of EN between January 1999 and December 2009 were included in the study retrospectively. Results It affected mainly middle-aged people,and the proportion of men and women was 1：6.8.The foremost etiology was tuberculosis infection （94,33.22%） followed in decreasing order by streptococcal infection （25,22.26%）; Connective tissue disease （19,6.71%）：Behcet disease （5,1.77%）,Sjogren syndrome （2,0.71%）,systemic lupus erythematosus （7,2.47%）,rheumatoid arthritis （5,1.77%）; lymphoma（2,0.71%）; unknown causes （66,23.32%）. The outcomes were usually favourable. Conclusion EN is a multiple-factor disease,closely involved with infection,and the common infections are caused by tubercle bacillus and streptococcal bacterium. Etiology and symptomatic treatment are very important.