期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

创伤性脑损伤后细胞凋亡及相关治疗研究 被引量：5

原文传递
导出
摘要 创伤性脑损伤（traumatic brain injury，TBI）具有高发病率和高死亡率，其原因大多为坠落伤所致，其次为斗殴和交通伤，轻型颅脑损伤的数量多于中、重型。TBI后脑组织主要的病理变化是神经细胞的坏死和凋亡，其中，bcl-2家族、caspases、p53以及早期反应基因等在TBI后的细胞凋亡中起着重要作用。抑制细胞凋亡能够减少凋亡的有害作用和促进功能恢复，
作者 袁章 杨拯 荣成 张晓
机构地区 成都医学院 成都医学院实验技术教研室
出处 《中华创伤杂志》 CAS CSCD 北大核心 2010年第7期669-672,共4页 Chinese Journal of Trauma
关键词 创伤性脑损伤 细胞凋亡 脑损伤后 CASPASES BCL-2家族 治疗 轻型颅脑损伤 早期反应基因
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献9

二级参考文献29

  • 1Chun-HuaHang,Ji-XinShi,Jie-ShouLi,Wei-QinLi,Hong-XiaYin.Up-regulation of intestinal nuclear factor kappa B and intercellular adhesion molecule-1 following traumatic brain injury in rats[J].World Journal of Gastroenterology,2005,11(8):1149-1154. 被引量：16
  • 2Marmarrou A, Foda MA, Vav-den-Brink W, et al. A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanics. J Neurosurg, 1994 ; 80(2) : 291.
  • 3Yoram S, Arthur M, Calvin C, et al. Therapeutic time window and dose response of the beneficial effects of ketamine in experimental head injury. Stroke, 1994; 25(8):1637.
  • 4Kaya SS, Mahmood A, Li Y, et al. Apoptosis and expression of p53 response protein and cyclin D1 after cortical impact in rat brain. Brain Research, 1999;818:23.
  • 5Khochbin S, Lawrece JJ. Processing of p53 mRNA during induced differentiation of murine erythroleukemia cells: is an altered splicing mechanism responsible for the posttranscrlptional control of gene expression? Gene, 19981 72 :77.
  • 6Harper JW, Adami OR, Wei N, et al. The p21 Cdk-interacting protein Cipl is a potent inhibitor of G1 cyclin-dependent kinases. Cell, 1993;75(1):80.
  • 7Macgibbon GA, Lawlor PA, Sirmanne ES, et al. Bax expression in mammalian neurons undergoing apoptosls, and in Alzheimer's disease hippocampus. Brain Res, 1997; 750 (3) :223.
  • 8Semenza G H. HIF-1α: mediator of physiological and pathophysiological reponses to hypoxia [J].J Appl Physio, 2000,88 : 1474.
  • 9王国强 廖维宏 等.重组腺病毒介导的BDNF基因转移对大鼠创伤性脑损伤后海马细胞凋亡的影响[J].中华创伤杂志,2000,17(5):264-268.
  • 10Keane RW, Kraydieh S, Lotocki G, et al. Apoptotic and antiapoptotic mechanisms after traumatic brain injury. J Cereb Blood Flow bletab,2001, 21(10):1189.

共引文献74

同被引文献91

  • 1陈春花,胡琴,杨磊,王珂,周长满.小檗碱对局部脑缺血组织中HIF-1α表达的影响[J].解剖学报,2007,38(4):394-399. 被引量：7
  • 2Sande A, West C. Traumatic brain injury: a review of pathophysiology and management [ J ]. J Vet Emerg Crit Care ( San Antonio) ,2010,20(2) : 177-190.
  • 3Fenyo IM, Florea IC, Raicu M, et al. Tyrphostin AG490 re- duces NAPDH oxidase activity and expression in the aorta of hypercholesterolemic apolipoprotein E-deficient mice [ J ]. Vascul Pharmaco1,2011,54 (3 -6 ) : 100-106.
  • 4Dowlati A, Nethery D, Kern JA. Combined inhibition of epidermal growth factor receptor and JAK/STAT pathways results in greater growth inhibition in vitro than single agent therapy [ J ]. Mol Cancer Ther,2004,3 (4) :459-463.
  • 5Barton BE, Karras JG, Murphy TF, et al. Signal transducer and activator of transcription 3 (STAT3) activation in prostate cancer:Direct STAT3 inhibition induces apoptosis in prostate cancer lines [ J 1. Mol Cancer Ther, 2004,3 (1) :11-20.
  • 6Tsuchiya Y, Takahashi N, Yoshizaki T, et al. A Jak2 inhi bitor, AG490, reverses lipin-1 suppression by TNF-alpha in 3T3-L1 adipocytes [ J]. Biochem Biophys Res Commun, 2009,382 (2) :348-352.
  • 7Saita K, Iwashita J, Murata J, et al. The tyrosine kinase in-hibitor AG490 inhibits growth of cancer cells and activates ERK in LS174T and HT 29 cells [ J ]. Anticancer Res, 2006,26 (2A) :1085-1090.
  • 8Tsenter J,Beni-Adani L, Assaf Y, et al. Dynamic changes in the recovery after traumatic brain injury in mice:effect of injury severity on T2-weighied MRI abnormalities, and motor and cognitive functions[ J]. J Neurotrauma,2008,25 (4) :324-333.
  • 9Reilly P, The impact of neurotrauma on society:an inter- national perspective [ J ]. Prog Brain Res, 2007,161 : 3-9.
  • 10Losiniecki A, Shutter L. Management of traumatic brain in- jury [ J ]. Curr Treat Options Neurol, 2010, 12 ( 2 ) : 142-154.

引证文献5

二级引证文献9

中华创伤杂志
2010年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部