加味玉屏风散对慢性阻塞性肺疾病急性加重期患者的影响

Influence of Modified Yu Ping Feng Pulvis on Inpatients with Chronic Obstructive Pulmonary Disease at Acute Exacerbation Stage

目的:观察加味玉屏风散对慢性阻塞性肺疾病(Chronic obstructive pulmonary disease,COPD)急性加重期患者肺功能[第1秒用力呼气量占预计值百分比(FEV1%pred)]、六分钟步行试验(6MWT)、临床症候积分、超氧化物歧化酶(SOD)、丙二醛(MDA)的影响。方法:将102例慢性阻塞性肺病急性加重期(AECOPD)患者随机分为加味玉屏风散治疗组(51例)和病例对照组(51例),选择同期本院健康体检者50例作为健康对照组。病例对照组给予常规治疗;治疗组在常规治疗基础上加用加味玉屏风散,治疗均为8周。观察两组临床疗效以及观察治疗前后的FEV1%pred、6MWT、SOD、MDA的变化。结果:两组的FEV1%pred、6MWT、SOD均较正常组降低,有统计学意义(P<0.05);两组的临床症候积分、MDA均较正常组升高,有统计学意义(P<0.05)。治疗组与病例对照组相比较,经过8周后治疗,FEV1%pred、、6MWT、SOD有升高;且治疗组较病例对照组FEV1%pred、SOD升高,有显著差异(P<0.05)。治疗组经过8周治疗,临床症候积分、MDA治疗后均较病例对照组明显下降(P<0.05),且有统计学意义(P<0.05)。结论:AECOPD患者SOD降低,MDA升高,存在氧化/抗氧化失衡;加味玉屏风散能下调COPD患者MDA、升高SOD水平,并减轻临床症状,改善其肺功能。

OBJECTIVE： To observe the effect of Yu Ping Feng Pulvis on pulmonary function the percentage of FEV1 /anticipated value（ FEV1% pred）、6MWT、symptom scores、SOD and MDA with acute exacerbation chronic obstructive pulmonary diseases（AECOPD）. MEDTHODS： 102 patients with AECOPD were selected from Department of Respiration,from January 2007 to December 2007. They were randomly divided into two groups： case control group （conventional therapy） and therapy group （ conventional therapy combined with modified Yu Ping Feng Pulvis）. Meanwhile 50 healthy volunteers,who underwent physical examination,were taken as the normal control group. FEV1% pred、6MWT and symptom scores were measured. Changes of SOD and MDA of AECOPD patients were determined before and after treatment respectively. RESULTS： In AECOPD patients before treatment,FEV1% pred、 6MWT and SOD were significantly lower than those of normal control group; while and MDA and symptom scores were significantly higher than those of normal control group （P 0. 05）. FEV1% pred and SOD were obviously higher while MDA and symptom scores were obviously lower in therapy group after 8 weeks treatment than in case control group （P 0. 05）; while MDA and symptom scores were significantly higher than those of normal control group（P 0. 05）. FEV1% pred and SOD were obviously higher while MDA and symptom scores were obviously lower in therapy group after 8 weeks treatment than in case control group. CONCLUSIONS： SOD and MDA are abnormal in AECOPD patients are also involved in oxidative stress in COPD. Yu Ping Feng Pulvis can downregulate MDA and upregulate SOD levels; can improve pulmonary function and symptom in AECOPD patients.