我院690例药品不良反应报告分析

ADR Repors of Our Hospital: An Analysis of 287 Cases

目的:对我院药品不良反应(ADR)报告进行分析,探讨ADR发生的特征,挖掘预警信号,为临床安全用药提供参考。方法:对我院收集到的690例ADR有效报告,按患者年龄、性别、给药途径、ADR程度、药品类型、ADR涉及器官或系统及临床表现等进行分类统计与分析。结果:60岁以上个案占38.4%,ADR发生频率与年龄有一定的相关性,但无性别差异;涉及药品12类351种,主要为抗感染药(占25.07%)和中成药(占14.53%),引起严重ADR的药物主要为抗感染药和抗肿瘤药;静脉给药方式是引发ADR的重要给药途径(占56.5%);30.29%ADR临床表现为皮肤及其附件损害。结论:应进一步加强对抗感染药、中成药及抗肿瘤药的安全性监测,指导临床合理用药,减少ADR的重复发生。

OBJECTIVE： To analyze the characteristics of the adverse drug reactions （ ADRs） occurred in our hospital and dig the prewarning signal to provide reference for clinical rational drug use. METHODS： A total of 690 ADR case reports collected from our hospital were subjected to a statistical analysis in respect of patients’age and sex, route of administration,ADR extent,drug categories,organs or system involved and clinical manifestations etc. RESULTS： 38. 4% of the patients showing ADRs were aged above 60 years; ADR incidence has certain correlation with age,but without sex difference. A total of 12 categories （351 kinds） of drugs were involved,predominantly anti infective drugs （25. 07% ） and Chinese patent drugs （14. 53% ）. The severe ADRs were mostly induced by anti infective drugs and antineoplastic agents. 56. 5% were induced by intravenous administration. 30. 29% of the ADR manifested as lesions of skins and its appendages. CONCLUSION： Further efforts should be taken to tighten monitoring on the safety of Chinese patent drugs,anti infective drugs and antineoplastic agents and offer guidance in clinical rational drug use to reduce the repeated occurrence of ADRs.