上皮—间质转化与恶性肿瘤的侵袭转移

Epithelial-mesenchymal transformation in malignant tumor invasion and metastasis

转移是肿瘤发展的一个重要阶段,且多数患者逝于肿瘤转移,所以肿瘤转移一直备受关注。上皮—间质转化(EMT)在恶性肿瘤的侵袭转移过程中发挥着关键的作用,而研究EMT的始发因素及其下游通路在肿瘤生长、侵袭、转移中的作用,阻断这一机制的发生发展,对恶性肿瘤的侵袭转移前的早期诊断、早期治疗有着非常重要的意义。下面就上皮—间质转化及其在组织胚胎发育过程中的作用、涉及的有关信号通路、与肿瘤侵袭转移的关系和在口腔恶性肿瘤侵袭转移中的作用等作一综述。

Cancer metastasis is an important stage in its development, and the majority of patients died of metastasis. So the transfer has been a hot area of cancer research. Studies suggest that epithelial-mesenchymal transformation（EMT） plays a key role in malignant tumor invasion and metastasis. Studys of the origin factor in EMT and its downstream pathway in tumor growth, invasion and metastasis, and how to block this mechanism have great significance, in the early diagnosis and early treatment of the malignant tumors. Here we will give you a review about the role of epithelial-mesenchymal transformation in the embryonic tissue development, the relevant signaling pathways involved, tumor invasion and metastasis and the role in invasion and metastasis of oral cancer.