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VNP20009在实体瘤治疗中的作用

Roles of VNP20009 in solid tumor therapy
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摘要 VNP20009是一种低致病性的减毒沙门菌,能够选择性地在实体肿瘤组织内复制并产生抗肿瘤效应,是肿瘤基因治疗的靶向载体。VNP20009与其他抗肿瘤方法联用可增强抗肿瘤疗效。下面就VNP20009的生物学特性和抗肿瘤作用等研究进展作一综述。 VNP20009, an attenuated strain of Salmonella typhimurium with low toxicity, selectively replicates in solid tumors and has intrinsic anti-tumor activity. VNP20009 is a promising tumor-targeting vector in gene therapy of tumors. Therapeutic effect will be enhanced by combination of VNP20009 therapy and other cancer therapies.
作者 李浩 胡勤刚
机构地区 南京大学医学院附属南京市口腔医院口腔颌面外科
出处 《国际口腔医学杂志》 CAS 2010年第4期440-443,共4页 International Journal of Stomatology
关键词 沙门菌属 VNP20009 肿瘤靶向性 基因治疗 载体 Salmonella VNP20009 tumor-targeting gene therapy vector
分类号 R730.5 [医药卫生—肿瘤]
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参考文献30

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二级参考文献10

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国际口腔医学杂志
2010年 第4期

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