摘要
肿瘤干细胞niche为肿瘤干细胞生存以及增殖分化提供了相对稳定的微环境,这一微环境由各种细胞、基质以及多种细胞因子等构成。在这一微环境中,肿瘤干细胞能够耐受放化疗。文献报道,破坏这种微环境能显著增强放化疗效果,从而改善肿瘤患者的预后。
Cancer stem cell niche provides a relatively stable microenvironment for cancer stem cell (CSC) existence, proliferation and differentiation. This microenvironment consists of kinds of cells, stroma and cytokines, etc. Within it , CSC can resist chemoradiotherapy. It has been shown that destruction of the microen vironment can significantly enhance the effect of chemoradiotherapy and improve prognosis of cancer patients.
出处
《国际肿瘤学杂志》
CAS
2010年第5期329-332,共4页
Journal of International Oncology
基金
国家自然科学基金资助项目(30973083)
关键词
肿瘤干细胞
生态系统
Neoplastic stem cells
Ecosystem