Toll样受体在肿瘤免疫治疗中的研究进展

Advances for toll- like receptors in cancer immunotherapy

Toll样受体（TLRs）是近10余年发现的主要在哺乳动物细胞表面进化上高度保守的受体分子家族，通过识别病原相关分子模式（PAMPs），在先天性免疫反应中发挥着关键作用，并且还能够诱导获得性免疫的产生。在某些肿瘤中TLRs的表达发生量的变化，并且许多微生物组分和药物能够通过TLRs信号通路介导肿瘤的免疫治疗。因此，对TLRs的深入研究将为肿瘤免疫治疗提供新的途径。

Toll like receptors （ TLRs）, a pattern conservative receptor superfamily are found on mammalian cell surface over the last decade. TLRs recognize distinct pathogen - associated molecular patterns, which can lead not only to the responses of the innate immunity but also to the development of the antigen- specific adaptive immunity. The expression of TLRs have changed in some carcinomas, besides, microbial composition and drugs mediate the tumor immunotherapy by the way of TLRs signal transduction. Consequently, deep studies on TLRs will provide new approaches for tumor immunotherapy.