Ki-67对早期乳腺癌治疗和预后的指导意义

Indicating significance of Ki-67 in therapy and prognosis of breast cancer

Ki-67是一种在增殖细胞中表达的核抗原，与临床分期、淋巴结状态和人表皮生长因子受体-2（Her-2）呈正相关，而与雌激素受体（EH）呈负相关。Ki-67高表达是细胞具有极度增殖活性的表现，内分泌治疗和化疗均对其表达有影响。Ki-67是早期乳腺癌的独立预后因素，亦可联合其他基因共同指导乳腺癌的预后，并可对乳腺癌的预后分级提供辅助信息。

Ki-67, as one kind of nucleoantigen expressed in proliferated cells, has positive correlation with clinical stage, nodal status and Her-2 ,while negative correlation with estrogen receptor（ER）. High Ki-67 expression influnced by endocrine therapy and chemotherapy indicates good proliferative activity. Ki-67, also as an independent prognostic factor of early breast cancer, provides prognostic information combined with other biologic markers. Ki-67 gives additional information breast cancer prognosis staging.