癌性贫血对肺癌患者生活质量及预后的影响

Impact of malignant tumor anemia on quality of life and prognosis in patients with lung cancer

目的:统计肺癌患者治疗前后癌性贫血发生率,分析其危险因素,探讨癌性贫血对肺癌患者生活质量(QOL)和预后的影响。方法:回顾性分析我院240例肺癌患者的临床资料,统计其治疗前后癌性贫血的发生率,分析其与性别、年龄、临床分期、PS评分、血清白蛋白水平和化疗的关系。应用QOL量表EORTCQLQ-C30中文版评价癌性贫血对肺癌患者QOL的影响,并探讨其对肺癌患者生存的影响。结果:240例肺癌患者,总体癌性贫血发生率为52.5%,治疗后癌性贫血发生率明显高于治疗前(15.8%,P=0.000)。化疗者癌性贫血发生率明显高于未化疗者(57.7%vs36.2%,P=0.004),化疗后明显高于化疗前(57.7%vs19.2%,P=0.000)。单因素和Logistic多因素回归分析均证实,年龄、临床分期、血清白蛋白水平及化疗是影响癌性贫血的危险因素(P均<0.05)。性别和病理类型与癌性贫血无关。癌性贫血明显影响肺癌患者的QOL;发生癌性贫血的患者生存期明显短于未发生癌性贫血者(9个月vs14个月,P=0.000)。Cox多因素回归分析证实,癌性贫血、临床分期、PS评分是影响肺癌患者预后的独立因素。结论:肺癌患者有较高的癌性贫血发生率,癌性贫血与年龄、临床分期、血清白蛋白水平及化疗密切相关,年龄越大、分期越晚,癌性贫血发生率越高越重。癌性贫血不但影响肺癌患者的QOL,还影响其预后。

OBJECTIVE：To analyze the incidence of malignant tumor anemia in pre-treatment and post-treatment of patients with lung cancer and the risk factors,and investigate the impact of malignant tumor anemia on quality of life（QOL）and prognosis in patients with lung cancer.METHODS：Clinical data of 240 patients with lung cancer were collected and retrospectively analyzed.Analysis the relationship of among gender,age,clinical stage,PS score,serum albumin levels and chemotherapy with malignant tumor anemia.Application of QOL Scale（EORTCQLQ-C30,Chinese version）to evaluate the impact of malignant tumor anemia on QOL in patients with lung cancer,and also investigate the impact on survival.RESULTS：A total of 240 cases of lung cancer patients,the overall incidence of malignant tumor anemia was 52.5%,the incidence of malignant tumor anemia in post-treatment was significantly higher than pre-treatment（15.8%,P=0.000）.The incidence of malignant tumor anemia in post-chemotherapy patients was higher than those without chemotherapy（57.7% vs 36.2%,P=0.004）,and it was also higher than pre-chemotherapy（57.7% vs 19.2%,P=0.000）.Univariate and Logistic multivariate regression analysis confirmed that age,clinical stage,serum albumin levels and chemotherapy are the risk factors in malignant tumor anemia（P〈0.05）,but there was no significant difference between different gender and pathology.Malignant tumor anemia significantly affect on QOL in patients with lung cancer;the survival of cancer-related anemia patients were significantly shorter than those without cancer-related anemia（9 months vs 14 months,P=0.000）,Cox multivariate regression analysis confirmed that malignant tumor anemia,clinical stage and PS score were the independent prognostic factors in patients with lung cancer.CONCLUSIONS：Patients with lung cancer has a higher incidence of malignant tumor anemia,malignant tumor anemia was closely related to age,clinical stage,serum albumin levels and chemotherapy,the later age and stage,the higher of the incidence of malignant tumor anemia.Malignant tumor anemia in patients with lung cancer significantly affects QOL and the prognosis.