乳腺小管癌的研究进展

Research progress of breast tubular carcinoma

目的:总结乳腺小管癌(TC)的相关研究,分析其临床病理学特征、诊断及鉴别诊断要点,探讨其预后相关因素和治疗方法的进展。方法:应用计算机检索PubMed及CNKI期刊全文数据系统,以"乳腺癌"和"小管癌"为关键词,检索1995-2010年相关文献共1025篇,纳入标准:1)TC的临床病理学特征、诊断及鉴别诊断、治疗方法和预后研究。2)TC的大样本病例(>30例)回顾性研究。排除≤10例的病例报道和重复性研究类文章,根据纳入标准符合分析的文献24篇。结果:小管癌具有较低的恶性程度,较早的临床和病理分期,良好的免疫组织化学结果,预后良好。保留乳房手术可以取得良好的治疗效果。结论:TC是一类恶性程度较低的非特殊浸润性乳腺癌,具有较好的生物学行为特性和较好的预后,保留乳房手术是其治疗的有效方式和发展方向。

OBJECTIVE：To summarize the related domestic and foreign research and explore the clinicopathologic characteristics,diagnosis and differential diagnosis of tubular carcinoma of breast,then study the prognosis and advance of the treatment methods.METHODS：A total of 1025 articles on tubular carcinoma of breast published between 1995 and 2010 were retrieved in PubMed and CNKI with the key words of ＇tubular carcinoma＇ and ＇breast cancer＇.Inclusion criteria：1）research of the clinicopathologic characteristics,diagnosis,differential diagnosis and treatment of breast tubular carcinoma.2）large sample（mare than 30 cases）retrospective study of breast tubular carcinoma.The case reports（less than 10 cases）and the research category duplicate were excluded.Twenty-four texts were selected by primary choice.RESULTS：All the articles take the same point as that the tubular carcinoma of breast is low potential malignancy with early clinical and pathologic stage,favorable immunohistochemistry consequences and prognosis.Conservative surgery is an effective treatment method.CONCLUSION：Breast tubular carcinoma is one of the special invasive carcinoma with low malignancy and favorable prognosis and conservative surgery is the effective treatment and research direction.