妇科恶性肿瘤患者心理因素对血清VEGF水平影响的研究

Psychosocial factors impacting serum VEGF levels of patients with gynecological malignancies

目的:探讨心理因素对妇科恶性肿瘤患者血清VEGF水平的影响。方法:采用对照研究的方法,运用临床心理评定量表(LES、CS、SSRS)对妇科恶性肿瘤患者组(n=80)、健康对照组(n=80)病前遭遇的生活事件、应付方式及社会支持进行问卷调查,同时用ELISA方法检测两组对象血清中的VEGF的水平,分析心理因素与血清VEGF水平的关系。结果:恶性肿瘤组患者负性生活事件频数及消极应对明显高于健康对照组,P<0.01;而积极应对、客观支持、主观支持以及对支持的利用度均低于健康对照组,P<0.01;妇科恶性肿瘤组患者血清VEGF值高于同期健康组,P<0.01。负性事件和消积应对与VEGF水平呈正相关,r值分别为0.618和0.432,P值均<0.01。而积极应对、客观支持以及主观支持均与VEGF呈负相关。结论:负性生活事件、不良应对方式及低的社会支持可促进妇科恶性肿瘤患者血清中VEGF水平的增高,与妇科恶性肿瘤的发生、发展密切相关。

OBJECTIVE： To explore the influence of psychosocial factors on the serum VEGF levels of patients with gynecological malignancies.METHODS： Eighty patients with gynecologic cancer and 80 healthy persons were asked to complete the Life Events Scale（LES）,Trait Coping Styles Questionnaire（TCSQ）,and Social Support Rating Scale（SSRS）,and the levels of serum VEGF were examined by mean of ELISA.The correlation between psychosocial factors and the serum VEGF levels was analyzed in the patients with gynecologic cancer.RESULTS： The frequency of negative life events and negative coping style among the patients with gynecologic cancer were significantly higher than those of the controls（P〈0.01）.The scores of positive coping style and social support were much lower（P〈0.01）.The levels of serum VEGF of the patients with gynecologic cancer were significantly higher than those of the controls（P〈0.01）,with negative events,negative response to a positive correlation,which r values were 0.618 and 0.432 respectively,and P values were both 〈0.01,and with a positive coping style and social support to a negative relation.CONCLUSION：The negative life events,low social support and poor coping styles can increase the level of serum VEGF of the patients with gynecologic cancer,and it is closely linked with gynecological cancer occurrence and development.