前列腺癌组织卵泡刺激素受体表达临床意义的研究

Expression and significance of follicle-stimulating hormone receptor in prostate cancer

目的:探讨卵泡刺激素受体在前列腺癌组织中的表达及其临床意义。方法:采用SP免疫组化方法,分析12例正常前列腺(NP)、14例前列腺增生(BPH)、45例前列腺癌(PCa)标本中FSHR的阳性表达情况和45例PCa标本中雄激素受体(AR)的表达情况。结果:NP组仅2例FSHR表达阳性,BPH组4例表达阳性,PCa组38例表达阳性,NP组与BPH组比较差异无统计学意义,BPH组与PCa组比较差异有统计学意义;FSHR在PCa组的表达程度与不同病理分级、临床分期和Gleason分级呈正相关。结论:FSHR在前列腺癌组织中的表达明显强于良性增生和正常的前列腺组织;FSHR与前列腺癌的发生、发展、转移等生物学行为有密切关系。

OBJECTIVE： To explore the significance of follicle-stimulating hormone receptor in prostate cancer throngh the research of the expression of FSHR in normal human prostate,benign prostatic hyperplasia and prostate cancer.METHODS： FSHR expressions were observed in 12 cases of normal specimens,14 cases of BPH and 45 cases of PCa tissues by immunohistochemical staining.RESULTS： There were 2 positive in normal prostate,4 positive in benign prostatic hyperplasia and 38 positive in prostate cancer.There was no significant difference between normal prostate and benign prostatic hyperplasia.But there was a significant difference between benign prostatic hyperplasia and prostate cancer.The postive rate of FSHR corresponded with the increase of tumor＇s pathological grading and its clinical staging,and furthermore with deeper color in cytoplasm.CONCLUSIONS： The expression of FSHR is higher in prostate cancer than that in normal human prostate and in benign prostatic hyperplasia,and the expression in prostate cancer presents a positive correlation with tumor＇s,sgrading and staging.The expression presents a close relation with the carcinogenesis,progression and metastasis of prostate cancer.