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基因与MTX副作用的相关性的新进展

Correlation of Gene with Anti-folate Agent MTX Side Effects
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摘要 抗叶酸剂MTX被运用于急性成淋巴细胞白血病,非霍奇金淋巴瘤,骨肉瘤,银屑病,类风湿性关节炎等疾病的治疗当中,但在临床上给病人相同剂量的MTX时,病人的反应及毒性的种类也大为不同。这多样性从一定程度上来说和基因的连续变更有关,本文章主要从亚甲基四氢叶酸还原酶(MTHFR)基因,MTX跨膜运输中的两种流出载体基因和MTX新陈代谢相关的四种基因中的单核苷酸多态性(SNP)两方面来阐述MTX在不同病人中出现的不良反应的新进展。 The antifolate methotrexate is widely used in the treatment of acutelymphoblastic leukaemia,non-Hodgkin lymphoma,osteosarcoma,Psoriasis,andRheumatoid Arthritis Even when given identical methotrexate doses,patients vary significantly in their response and pattern of toxicities.This diversity can,to some extent,be linked to sequence variations in genes.This paper mainly talk about the advance of toxicity which is in different patient from the methylenetetrahydrofolate reductase（MTHFR） gene and single nucleotide polymorphisms（SNPs） across four genes that are relevant to methotrexate metabolism and the two efflux transporter genes in methotrexate transmembrane.
作者 王丽娜 普雄明
机构地区 新疆医科大学 新疆维吾尔自治区人民医院皮肤性病科
出处 《现代生物医学进展》 CAS 2010年第13期2578-2580,共3页 Progress in Modern Biomedicine
关键词 亚甲基四氢叶酸还原酶 单核苷酸多态性 甲氨蝶呤 副作用 MTHFR SNP MTX Toxity
分类号 Q75 [生物学—分子生物学] R979.12 [医药卫生—药品]
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参考文献27

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二级参考文献7

  • 1SOHN K J, CROXFORD R, YATES Z, et al. Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate[ J]. J Natl Cancer last,2004,96(2) :134-144.
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  • 5VAN EDE A E, LAAN R F, BLOM H J, et al. The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients[J]. Arthritis Rheum, 2001,44( 11 ) : 2525-2530.
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  • 7缪小平,邢德印,谭文,吕文富,林东昕.MTHFR基因C677T和A1298C多态与贲门癌的遗传易感性[J].中华医学杂志,2002,82(10):669-672. 被引量：17

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现代生物医学进展
2010年 第13期

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