摘要
药物依赖是一种慢性、复发性的脑疾病,可引起大脑发生病理性变化。在我国滥用的毒品主要是阿片类物质,阿片类物质依赖包括身体依赖(表现为停药后的戒断症状)和精神依赖(表现为满足感和重新用药的渴求)。与阿片依赖及耐受相关的因素有内源性阿片肽、阿片受体及其受体后信号转导系统功能状态的适应性改变等。本文就与阿片依赖有关的细胞内信号转导机制作一综述。
Drug dependence is a chronic,relapsing disease,characterized by compulsive drug caving and use and by neurochemical and molecular changes in the brain.In our country the drug of abuse is mostly the material of opioid type.Two concepts contribute to opioid dependence：physical dependence,manifested by a withdrawal syndrome produced by abrupt cessation of opioid,and psychologic dependence,accompanied by feelings of satisfaction and a desire to repeat the drug experience or to avoid the discontent of not having it.Endogenous opioid、opioid receptor and adaptability changes of signal transudations are involved in opioid dependence.This article reviewed the signal transudations mechanism of opioid dependence.
出处
《现代生物医学进展》
CAS
2010年第13期2581-2583,共3页
Progress in Modern Biomedicine
关键词
阿片依赖
阿片戒断
信号转导
Opioid dependence
Opioid withdrawal
Signal transudations
